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Resistance and tolerance mechanisms to antifungal drugs in fungal pathogens

Published online by Cambridge University Press:  03 December 2003

DOMINIQUE SANGLARD
DOMINIQUE SANGLARD
Affiliation:
Institute of Microbiology, University Hospital Lausanne, CH-1011 Lausanne, Switzerland
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Abstract

Fungal pathogens are using several mechanisms to circumvent the inhibitory actions of antifungal drugs. The variety of these mechanisms was revealed in recent years by several laboratories with molecular approaches. Besides the identification of genes involved in antifungal drug resistance and the discovery of alternative pathways of resistance (i.e. biofilm formation), novel concepts in the understanding of the survival of fungal pathogen in the presence of antifungal drug (antifungal tolerance) have emerged.

Keywords

Fungiantifungal agentsazolesresistancetolerancemultidrug transporterscytochrome P450biofilmsmicroarrays
Type
Original Article
Information
Mycologist , Volume 17 , Issue 2 , May 2003 , pp. 74 - 78
Copyright
© 2003 Cambridge University Press

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