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Time Interval and Continuous Testing of Stimuli Responsive Hydrogels

Published online by Cambridge University Press:  07 January 2014

Jeffrey S. Bates  and
Jules J. Magda
Jeffrey S. Bates
Affiliation:
Department of Materials Science and Engineering, University of Utah, 122 Central Campus Drive, Room 304, Salt Lake City, UT 84112, U.S.A.
Jules J. Magda
Affiliation:
Department of Chemical Engineering, University of Utah, 50 Central Campus Drive, Room 3290, Salt Lake City, UT 84112 U.S.A.
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Abstract

Researchers have investigated hydrogels as potential materials for biological monitoring. Hydrogel compositions have been designed to respond to changes in temperature, pH, glucose concentration and ionic strength concentration. Hydrogels designed to respond to changes in environmental conditions have demonstrated their ability to respond via a swelling or shrinking action. This swelling behavior can be exploited using a variety of signal transduction methods. While this technology shows promise, the degradation of hydrogel materials has not yet been characterized with respect to the shelf life of hydrogel samples or to their use in continuous testing. A series of experiments were performed to test hydrogels stored for extended periods of time then subjected to oscillatory testing, and the results have been analyzed to determine whether hydrogels can be used for extended periods of time for biological sensing applications.

Keywords

chemical synthesision-exchange materialpolymer
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1622: Symposium E – Fundamentals of Gels and Self-Assembled Polymer Systems , 2014 , pp. 153 - 159
Copyright
Copyright © Materials Research Society 2014 

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References

REFERENCES

De, S. K., Aluru, N. R., Johnson, B., Crone, W. C., Beebe, D. J., Moore, J., Equilibrium swelling and kinetics of pH-responsive hydrogels: models, experiments and simulations, Journal of Microelectromechanical Systems 11 (2002) 544–555.CrossRefGoogle Scholar
Bienes, P. W., Klosterkamp, I., Menges, B., Jonas, U., Knoll, W., Responsive thin hydrogel layers from photo-cross-linkable poly (N-isopropylacrylamide) terpolymers, Langmuir 23 (2007) 2231–2238.CrossRefGoogle Scholar
Liu, M., Guo, T., Preparation and swelling properties of crosslinked sodium polyacrylate, Journal of Applied Polymer Science 82 (2001) 1515–1520.CrossRefGoogle Scholar
Kuckling, D., Hoffman, J., Plotner, M., Ferse, D., Kretschmer, K., Adler, H. P., Arndt, K., Reichelt, R., Photo cross-linkable poly(N-isopropylacrylamide) copolymers III: micro-fabricated temperature responsive hydrogels, Polymer 44 (2003) 4455–4462.CrossRefGoogle Scholar
Shin, J., Braun, P. V., Lee, W., Fast responsive photonic crystal pH sensor based on template photo-polymerized hydrogel inverse opal, Sensors and Actuators B: Chemical 150 (2010) 183–190.CrossRefGoogle Scholar
Iwata, T., Suzuki, K., Amaya, N., Higuchi, H., Masunaga, H., Sasaki, S., Kikuchi, H., Control of cross-linking polymerization kinetics and polymer aggregated structure in polymer-stabilized liquid crystalline blue phases, Macromolecules 42 (2009) 2002–2008.CrossRefGoogle Scholar
Galeav, I. Y., Mattiason, B., Smart polymers and what they could do in biotechnology and medicine, Trends in Biotechnology 17 (1999) 335–340.CrossRefGoogle Scholar
Bates, J.S., Cho, S.H., Tathireddy, P., Rieth, L.W., Magda, J.J., Smart Hydrogels Designed for Used in Microfabricated Sensor Arrays, MRS Proceedings 1570 (2013) 1–6 Google Scholar
Lin, G., Chang, S., Kuo, C.-H., Magda, J., Solzbacher, F., Free swelling and confined smart hydrogels for applications in chemomechanical sensors for physiological monitoring, Sensors and Actuators B: Chemical 136 (2009) 186–195.CrossRefGoogle ScholarPubMed
Schulz, V., Guenther, M., Gerlach, G., Magda, J. J., Tathireddy, P., Rieth, L., Solzbacher, F., In-vitro investigations of a pH- and ionic-strength-responsive polyelectrolyte hydrogel using a piezoresistive microsensor, Smart Struct Mater Nondestruct Eval Health Monitor Diagn 7827 (2009) 1–16.Google Scholar
Gerlach, G., Guenther, M., Sorber, J., Suchanek, G., Chemical and pH sensors based on the swelling behavior of hydrogels, Sensors and Actuators B 111 (2005) 555–561.CrossRefGoogle Scholar