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Synthesis of water-soluble, magnetic Fe/Au nanoparticles

Published online by Cambridge University Press:  01 February 2011

Katherine A. Brown ,
Andy Wijaya ,
Joshua D Alper  and
Kimberly Hamad-Schifferli
Katherine A. Brown
Affiliation:
[email protected], Massachusetts Institute of Technology, Biological Engineering, 77 Massachusetts ave, 56-354, Cambridge, Ma, 02139, United States, 617-324-0250
Andy Wijaya
Affiliation:
[email protected], Massachusetts Institute of Technology, Chemical Engineering, United States
Joshua D Alper
Affiliation:
[email protected], Massachusetts Institute of Technology, Mechanical Engineering, United States
Kimberly Hamad-Schifferli
Affiliation:
[email protected], Massachusetts Institute of Technology, Mechanical Engineering and Biological Engineering, United States
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Abstract

We report the synthesis of water soluble, monodisperse Fe/Au bimetallic nanoparticles with an average diameter of 7nm. Synthesis involves simultaneous reduction of Fe3+ and Au3+ in water to yield bimetallic nanoparticles. The elemental content of Fe is 1.5%. Nanoparticles exhibit ferromagnetic behavior as measured by SQUID. These particles can be easily conjugated to thiolated DNA, as evidenced by mobility shifts in agarose gel electrophoresis. Nanoparticles heat in solution to temperatures above 40°C, indicating suitability for hyperthermia.

Keywords

nanoscaleAumagnetic
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 900: Symposium O – Nanoparticles and Nanostructures in Sensors and Catalysis , 2005 , 0900-O07-01
Copyright
Copyright © Materials Research Society 2006

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References

REFERENCES

(1) Chemla, Y. R.; Grossman, H. L.; Poon, Y.; McDermott, R.; Stevens, R.; Alper, M. D.; Clarke, , J. Proc. Natl. Acad. Sci. USA 2000, 97, 14268–14272.Google Scholar
(2) Perez, J. M.; Josephson, L.; O'Loughlin, T.; Högemann, D.; Weissleder, R. Nat. Biotechnol. 2002, 20, 816–820.Google Scholar
(3) Berry, C. C.; Curtis, A. S. G. J. Phys. D: Appl. Phys 2003, 36, R198–R206.Google Scholar
(4) Kawashima, Y. Adv. Drug. Deliver. Rev. 2001, 47, 1–2.Google Scholar
(5) Wang, J.; Kawde, A.-N.; Erdem, A.; Salazar, M. The Analyst 2001, 126, 2020–2024.Google Scholar
(6) Högemann, D.; Ntziachristos, V.; Josephson, L.; Weissleder, R. Bioconjugate Chem. 2002, 13, 116–121.Google Scholar
(7) Sun, S.; Zeng, H.; Robinson, D. B.; Raoux, S.; Rice, P. M.; Wang, S. X.; Li, G. J. Am. Chem. Soc. 2004, 126, 273–279.Google Scholar
(8) Hyeon, T.; Lee, S. S.; Park, J.; Chung, Y.; Na, H. B. J. Am. Chem. Soc. 2001, 123, 12798–12801.Google Scholar
(9) Puntes, V. F.; Krishnan, K. M.; Alivisatos, A. P. Science 2001, 291, 2115–2117.Google Scholar
(10) Rockenberger, J.; Scher, E. C.; Alivisatos, A. P. J. Am. Chem. Soc. 1999, 121, 11595–11596.Google Scholar
(11) Robinson, D. B.; Persson, H. H. J.; Zeng, H.; Li, G.; Pourmand, N.; Sun, S.; Wang, S. X. Langmuir 2005, 21, 3096–3103.Google Scholar
(12) Wang, Y.; Wong, J. F.; Teng, X.; Lin, X. Z.; Yang, H. Nano Lett. 2003, 3, 1555–1559.Google Scholar
(13) Josephson, L.; Perez, J. M.; Weissleder, R. Angew. Chem., Int. Ed. Engl. 2001, 40, 3204–3206.Google Scholar
(14) Zanchet, D.; Micheel, C. M.; Parak, W. J.; Gerion, D.; Alivisatos, A. P. Nano Lett. 2001, 1, 32–35.Google Scholar
(15) Elghanian, R.; Storhoff, J. J.; Mucic, R. C.; Letsinger, R. L.; Mirkin, C. A. Science 1997, 277, 1078–1081.Google Scholar
(16) McMillan, R. A.; Paavola, C. D.; Howard, J.; Chan, S. L.; Zaluzec, N. J.; Trent, , J. D. Nat. Mater. 2002, 1, 247–252.Google Scholar
(17) Nicewarner-Peña, S. R.; Raina, S.; Goodrich, G. P.; Fedoroff, N. V.; Keating, C. D. J. Am. Chem. Soc. 2002, 124, 7314–7323.Google Scholar
(18) Aubin, M.-E.; Morales, D. G.; Hamad-Schifferli, K. Nano Lett. 2005, 5, 519–522.Google Scholar
(19) Jhaveri, S. D.; Foos, E. E.; Lowy, D. A.; Chan, E. L.; Snow, A. W.; Ancona, M. G. Nano Lett. 2004, 4, 737–740.Google Scholar
(20) Parak, W. J.; Pellegrino, T.; Micheel, C. M.; Gerion, D.; Williams, S. C.; Alivisatos, A. P. Nano Lett. 2003, 3, 33–36.Google Scholar
(21) Park, S.; Brown, K. A.; Hamad-Schifferli, K. Nano Lett. 2004, 4, 1925–1929.Google Scholar
(22) Hirsch, L. R.; Stafford, R. J.; Bankson, J. A.; Sershen, S. R.; Rivera, B.; Price, R. E.; Hazle, J. D.; Halas, N. J.; West, J. L. Proc. Natl. Acad. Sci. USA 2003, 100, 13549–13554.Google Scholar
(23) Cao, Y. C.; Jin, R.; Mirkin, A., , C. Science 2002, 297, 1536–1540.Google Scholar
(24) Chou, C. K. Inter. J. Hyptherm. 1990, 6, 367–370.Google Scholar
(25) Hirsch, L. R.; Stafford, R. J.; Bankson, J. A.; Sershen, S. R.; Rivera, B.; Price, R. E.; Hazle, J. D.; Halas, N. J.; West, J. L. Proc. Natl. Acad. Sci. USA 2003, 100, 13549–13554.Google Scholar
(26) Shinkai, M.; Yanase, M.; Suzuki, M.; Honda, H.; Wakabayashi, T.; Yoshida, J.; Kobayashi, T. J. Magn. Magn. Mater. 1999, 194, 176–184.Google Scholar