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Synthesis of Size and Shape Controlled Silver Nanoparticles Coated by a Thin Layer of Gold and Their Use as Ultrasensitive Biomolecular Probes

Published online by Cambridge University Press:  01 February 2011

Derrick Mott ,
Nguyen Thi Bich Thuy ,
Yoshiya Aoki  and
Shinya Maenosono
Derrick Mott
Affiliation:
[email protected]
Nguyen Thi Bich Thuy
Affiliation:
[email protected], Japan Advanced Institute of Science and Technology, Nomi, Japan
Yoshiya Aoki
Affiliation:
[email protected], Japan Advanced Institute of Science and Technology, Nomi, Japan
Shinya Maenosono
Affiliation:
[email protected], Japan Advanced Institute of Science and Technology, School of Materials Science, Nomi, Japan
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Abstract

Silver nanoparticles coated by a layer of gold (Ag@Au) have received much attention because of their potential application as ultra sensitive probes for the detection of biologically important molecules such as DNA, proteins, amino acids and many others. However, the ability to control the size, shape, and monodispersity of the Ag@Au structure has met with limited success. In our own research we have addressed this challenge by creating an aqueous wet chemical synthesis technique towards size and shape controllable Ag@Au nanoparticles. These materials are highly interesting because of the tunable silver core size, and the tunable gold shell thickness, opening many avenues to the modification of the particle properties in terms of bio-molecular sensing. The resulting nanoparticle probes were functionalized with two complementary stranded DNA oligonucleotides. When combined, the complementary strands hybridized, causing the Ag@Au nanoparticles to assemble into large nano-structures. The presence of the oligonucleotide was confirmed through a series of techniques including UV-Vis and RAMAN spectroscopy, as well as HR-TEM, XPS, DLS, and many others. The results reflect the role that the nanoparticle physical properties play in the detection of the bio-molecules, as well as elucidate the characteristics of the bio-molecule/nanoparticle interaction.

Keywords

AuAgcore/shell
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1253: Symposium K – Functional Materials and Nanostructures for Chemical and Bochemical Sensing , 2010 , 1253-K09-04
Copyright
Copyright © Materials Research Society 2010

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