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Synthesis and Characterization of Supported Bioactive Lipid Membranes

Published online by Cambridge University Press:  15 February 2011

Theodore M. Winger  and
Elliot L. Chaikof
Theodore M. Winger
Affiliation:
School of Chemical Engineering, Georgia Institute of Technology, Atlanta, GA 30332
Elliot L. Chaikof
Affiliation:
School of Chemical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322
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Abstract

Single and multicomponent membrane-mimetic surfaces of DPPC and synthetic lipid-peptide conjugates were formed on an alkylated glass surface by a process of vesicle fusion. Correlative atomic force microscopy and radiochemical titration techniques confirmed the generation of a single substrate supported monolayer and predictable deposition of defined concentrations of lipopeptide. Mixed systems were stable for periods exceeding 1 month if stored at room temperature in phosphate buffered saline.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 489: Symposium K – Materials Science of the Cell , 1997 , 113
Copyright
Copyright © Materials Research Society 1998

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