Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-23T13:13:17.202Z Has data issue: false hasContentIssue false
  • English
  • Français

Swelling and Release Properties of Functional κ-carrageenan Hydrogel Nanocomposites

Published online by Cambridge University Press:  27 February 2012

Ana Luísa Daniel da Silva ,
Ana M. Salgueiro ,
Sara Fateixa ,
Joana Moreira ,
Ana C. Estrada ,
Ana M. Gil  and
Tito Trindade
Ana Luísa Daniel da Silva
Affiliation:
CICECO and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
Ana M. Salgueiro
Affiliation:
CICECO and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
Sara Fateixa
Affiliation:
CICECO and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
Joana Moreira
Affiliation:
CICECO and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
Ana C. Estrada
Affiliation:
CICECO and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
Ana M. Gil
Affiliation:
CICECO and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
Tito Trindade
Affiliation:
CICECO and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
Get access

Abstract

Today polysaccharide based hydrogel nanocomposites are receiving high importance as biomaterials for drug delivery. Inorganic nanoparticles (NPs) are incorporated into the polymer matrix to provide novel functionalities to the hydrogels. However, the effect of nanofillers on the release properties has not been totally understood. In this work, we investigate the influence of inorganic functional nanofillers (Fe3O4 and Au NPs) with variable size and shape on the structure of κ-carrageenan hydrogels and on the kinetics and release mechanism of methylene blue (MB) as model drug. It was shown that, depending on the nature of the nanofiller incorporated, and for equivalent nanofiller content, the mechanism of MB release can be adjusted either to by diffusion or polymer relaxation mechanism. The mechanism of the MB release was found to be determined by the strength and microstructure of the gel network and extent of gel swelling, which are affected by the extent of incorporation of the nanofillers.

Keywords

polymerbiomaterialnanostructure
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1403: Symposium V – Multifunctional Polymer-Based Materials , 2012 , mrsf11-1403-v14-04
Copyright
Copyright © Materials Research Society 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Dias, A.M.G.C., Hussain, A., Marcos, A.S. and Roque, A.C.A, Biotechnol. Adv. 29, 142 (2011).Google Scholar
2. Satarkar, N.S.; Biswal, D. and Hilt, J.Z., Soft Matter 6, 2364 (2010).Google Scholar
3. Choi, W.I., Kim, J.Y., Kang, C., Byeon, C.C. and Kim, Y.H., ACS Nano 5, 1995 (2011).Google Scholar
4. Daniel-da-Silva, A.L., Moreira, J., Neto, R., Estrada, A.C., Gil, A.M. and Trindade, T. Carbohyd. Polym. 87, 328 (2012).Google Scholar
5. Daniel-da-Silva, A.L., Ferreira, L., Gil, A.M. and Trindade, T., J. Colloid. Interf. Sci. 355, 512 (2011).Google Scholar
6. Santo, V.E., Frias, A.M., Carida, M., Cancedda, R., Gomes, M.E., Mano, J.F. and Reis, R.L. Biomacromolecules 10, 1392 (2009).Google Scholar
7. Daniel-da-Silva, A.L., Loio, R., Lopes-da-Silva, J.A., Trindade, T., Goodfellow, B. J. and Gil, A. M., J. Colloid. Interf. Sci. 324, 205 (2008).Google Scholar
8. Daniel-da-Silva, A.L., Fateixa, S., Guiomar, A.J., Costa, B.F.O., Silva, N.J.O., Trindade, T., Goodfellow, B.J. and Gil, A.M., Nanotechnology 20, 355602 (2009).Google Scholar
9. Turkevitch, J., Stevenson, P.C. and Hillier, J., Discuss. Faraday Soc. 11, 55 (1951).Google Scholar
10. Nikoobakht, B. and El-Sayed, M.A., Chem. Mater. 15, 1957 (2003).Google Scholar
11. Iijima, M., Hatakeyama, T., Takahashi, M. and Hatakeyama, H., Thermochim. Acta 452, 53 (2007).Google Scholar
12. Ritger, P.L. and Peppas, N.A., J. Control. Release 5, 37 (1987).Google Scholar
13. Soo, P. L., Cho, J., Grant, J., Ho, E., Piquette-Miller, M. and Allen, C., Eur. J. Pharm. Biopharm. 69, 149 (2008).Google Scholar