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Surface Modification of Polycarbonateurethane by Grafting Phosphorylcholine Glyceraldehydes for Improving Hemocompatibility

Published online by Cambridge University Press:  21 February 2012

Wei Gao ,
Yakai Feng ,
Jian Lu  and
Jintang Guo
Wei Gao
Affiliation:
School of Chemical Engineering and Technology, Tianjin University, Weijin Road 92, Tianjin, China
Yakai Feng
Affiliation:
School of Chemical Engineering and Technology, Tianjin University, Weijin Road 92, Tianjin, China Tianjin University-Helmholtz-Zentrum Geesthacht, Joint Laboratory for Biomaterials and Regenerative Medicine, Weijin Road 92, Tianjin, China
Jian Lu
Affiliation:
School of Chemical Engineering and Technology, Tianjin University, Weijin Road 92, Tianjin, China
Jintang Guo
Affiliation:
School of Chemical Engineering and Technology, Tianjin University, Weijin Road 92, Tianjin, China Tianjin University-Helmholtz-Zentrum Geesthacht, Joint Laboratory for Biomaterials and Regenerative Medicine, Weijin Road 92, Tianjin, China
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Abstract

Phosphorylcholine glyceraldehyde (PCGA) was used as a phosphorylcholine (PC) group containing compound to graft onto the surface of polycarbonateurethane (PCU) film using 1,6-hexanediamine (HDA) or α,ω-diamino-poly(ethylene glycol) (APEG, Mn = 200) as a spacer, in order to introduce biomimetic structure onto the polymer surface. X-ray photoelectron spectroscopy (XPS) analysis shows that PCGA has been covalently linked to the PCU surface. Water contact angle test suggests that the surface hydrophilicity has been improved after PCGA is grafted onto the surface of PCU film. Scanning electron microscope (SEM) observation of the modified PCU films after contacting with plasma-rich plasma demonstrates that platelets rarely adhere but a large number of platelets adhere to the original PCU surface. The hemocompatibility of the PC modified PCU film has been improved obviously after grafting with PCGA with PEG spacer.

Keywords

biomaterialbiomimetic (chemical reaction)surface chemistry
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1403: Symposium V – Multifunctional Polymer-Based Materials , 2012 , mrsf11-1403-v01-04
Copyright
Copyright © Materials Research Society 2012

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