Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-27T02:08:33.387Z Has data issue: false hasContentIssue false
  • English
  • Français

Suggested Strategies for the Ecotoxicology Testing of New Nanomaterials

Published online by Cambridge University Press:  26 February 2011

Vicki Stone ,
Teresa Fernandes ,
Alex Ford  and
Nick Christofi
Vicki Stone
Affiliation:
[email protected], Napier University, School of Life Sciences, Merchiston campus, Edinburgh, N/A, EH9 3EE, United Kingdom, 0044 131 455 2671, 0044 131 455 2291
Teresa Fernandes
Affiliation:
[email protected], Napier University, School of Life Sciences, United Kingdom
Alex Ford
Affiliation:
[email protected], Napier University, School of Life Sciences, United Kingdom
Nick Christofi
Affiliation:
[email protected], Napier University, School of Life Sciences, United Kingdom
Get access

Abstract

Nanotechnology is a rapidly expanding and advancing field of research that has already yielded a variety of commercially available products including cosmetics, suntan lotions, paints, self cleaning windows and stain resistant clothing. The Royal Society and the Royal Academy of Engineering in their recent report ‘Nanotechnology and nanoscience: opportunities and uncertainties’ (http://www.nanotec.org.uk/finalReport.htm) concluded that nanotechnology is likely to have ‘huge potential’. While this report indicated that ‘many applications of nanotechnology pose no new health or safety risks’, it also recognised that the health, safety and environmental hazards of nanoparticles (diameter less than 100nm) and nanotubes requires investigation. A significant body of data exists regarding the toxicological effects of nanoparticles (also termed ultrafine particles) in mammalian systems, particularly with respect to the lungs and cardiovascular system. Such studies suggest that smaller particles, with a larger surface area per unit mass, are more potent at inducing oxidative stress and inflammation leading to adverse health effects. However, very few papers have been published regarding the effects of nanoparticles on other phyla such as micro-organisms, invertebrates and vertebrates from terrestrial and aquatic habitats. Since nanoparticles from both domestic and industrial products will be released into the environment, eg. wastewater, it is essential to investigate the impact on such species and the ecosystem. This presentation will aim to discuss how existing knowledge regarding the mammalian toxicology of nanoparticles could be used to generate an effective, efficient and focused strategy for testing the ecotoxicolgy of nanoparticles.

Keywords

biologicalwaste managementparticulate
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 895: Symposium G – Life-Cycle Analysis Tools for “Green” Materials and Process Selection , 2005 , 0895-G04-03-S04-03
Copyright
Copyright © Materials Research Society 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Biswas, P., and Wu, C. Y. (2005). Nanoparticles and the environment. J.Air Waste Manag.Assoc. 55, 708–746.Google Scholar
Brant, J., Lecoanet, H., Hotze, M., and Wiesner, M. (2005). Comparison of electrokinetic properties of colloidal fullerenes (n-C60) formed using two procedures. Environ.Sci.Technol. 39, 6343–6351.Google Scholar
Brown, D. M., Wilson, M. R., MacNee, W., Stone, V., and Donaldson, K. (2001). Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol.Appl.Pharmacol. 175, 191–199.Google Scholar
Colvin, V. (2003) The potential environmental impact of engineered nanomaterials. Nat. Biotechnol. 21(10): 1166–1170.Google Scholar
Donaldson, K., Brown, G. M., Brown, D. M., Bolton, R. E., and Davis, J. M. (1989). Inflammation generating potential of long and short fibre amosite asbestos samples. Br.J.Ind.Med. 46, 271–276.Google Scholar
Donaldson, K., Stone, V., Borm, P. J., Jimenez, L. A., Gilmour, P. S., Schins, R. P., Knaapen, A. M., Rahman, I., Faux, S. P., Brown, D. M., and MacNee, W. (2003). Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10). Free Radic.Biol.Med. 34, 1369–1382.Google Scholar
Donaldson, K., Stone, V., Gilmour, P. S., Brown, D. M., and MacNee, W. (2000) Ultrafine particles: mechanisms of lung injury. Phil.Trans.R.Soc.Lond. 358, 2741–2749.Google Scholar
Duffin, R., Tran, C. L., Clouter, A., Brown, D. M., MacNee, W., Stone, V., and Donaldson, K. The importance of surface area and specific reactivity in the acute pulmonary inflammatory response to particles. Ann.Occup.Hyg. 46(Suppl. 1), 242–245. 2002.Google Scholar
Ferin, J., Oberdorster, G., and Penney, D. P. (1992). Pulmonary retention of ultrafine and fine particles in rats. Am.J.Respir.Cell Mol.Biol. 6, 535–542.Google Scholar
Giles, GI and Jacob, C. (2002). Reactive sulphur species: an emerging concept in oxidative stress. Biol. Chem., 34, 375–388.Google Scholar
Kim, S-C, Lee, D-K. 2005. Preparation of TiO2-coated hollow glass beads and their application to the control of algal growth in eutrophic water. Microchem J 80: 227–232.Google Scholar
Koper, O, Klabunde, KJ. 2000. Nanoparticles for the destructive sorption of biological and chemical contaminants. U.S. Patent 6, 057, 488; May 2.Google Scholar
Lee, S.-H. (2005). Inactivation of bacterial endospores by photocatalytic nanocomposites. Colloid Surface 40, 93–98.Google Scholar
Li, X. Y., Brown, D., Smith, S., MacNee, W., and Donaldson, K. (1999). Short-term inflammatory responses following intratracheal instillation of fine and ultrafine carbon black in rats. Inhal.Toxicol. 11, 709–731.Google Scholar
Lovern, S. B., and Klaper, R. D. (2006). Daphia magna mortality when exposed to titanium dioxide and fullerene (C60) nanoparticles. Environ.Toxicol.Chem In press.Google Scholar
Mato, Y., Isobe, T., Takada, H., Kanehiro, H., Ohtake, C., and Kaminuma, T. (2001). Plastic resin pellets as a transport medium for toxic chemicals in the marine environment. Environ.Sci.Technol. 35, 318–324.Google Scholar
Nature (2003) Dont believe the hype. Editorial. Nature 424; 237.Google Scholar
Oberdorster, E. (2004). Manufactured nanomaterials (Fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth Bass. Environ.Health Perspect. 112, 1058–1062.Google Scholar
Oberdorster, E., Zhu, S., Blickley, T. M., McClellan-Green, P., and Haasch, M. L. (2006). Ecotoxicology of carbon-based engineered nanoparticles: Effects of fullerene (C60) on aquatic organisms. Carbon In press.Google Scholar
Oberdorster, G., Oberdorster, E., and Oberdorster, J. (2005). Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ.Health Perspect. 113, 823–839.Google Scholar
Peters, A., Wichmann, H. E., Tuch, T., Heinrich, J., and Heyder, J. (1997). Respiratory effects are associated with the number of ultrafine particles. Am.J.Respir.Crit Care Med. 155, 1376–1383.Google Scholar
Sondi, I Salopek-Sondi, B. (2004). Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. J. Colloid Interface Sci., 275, 177–182.Google Scholar
Stone, V., Shaw, J., Brown, D. M., MacNee, W., Faux, S. P., and Donaldson, K. The role of oxidative stress in the prolonged inhibitory effect of ultrafine carbon black on epithelial cell function. Toxicol.In Vitro 12, 649–659. 1998.Google Scholar
Warheit, D. B., Driscoll, K. E., Oberdoerster, G., Walker, C., Kuschner, M., and Hesterberg, T. W. (1995). Contemporary issues in fiber toxicology. Fundam.Appl.Toxicol. 25, 171–183.Google Scholar
Watson, J. H. P., Cressey, B. A., Roberts, A. P., Ellwood, D. C., Charnock, J. M., and Soper, K. (2000). Structural and magnetic studies on heavy-metal-adsorbing iron sulphide nanoparticles produced by sulphate-reducing bacteria. J.Magn.Magn.Mat. 214, 13–20.Google Scholar
Wilson, M. R., Lightbody, J. H., Donaldson, K., Sales, J., and Stone, V. (2002). Interactions between ultrafine particles and transition metals in vivo and in vitro. Toxicol.Appl.Pharmacol. 184, 172–179.Google Scholar
Yang, L, Watts, D J. 2005. Particle surface characteristics may play an important role in phytotoxicity of alumina nanoparticles Toxicol Lett 158: 122–132.Google Scholar