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Structure and Properties of Murine and Human Dentin

Published online by Cambridge University Press:  01 February 2011

Stefan Habelitz ,
Shabnam Zartoshtimanesh ,
Mehdi Balooch ,
Sally J. Marshall ,
Grayson W. Marshall  and
Pamela K. DenBesten
Stefan Habelitz
Affiliation:
Department of Preventive and Restorative Dental Sciences
Shabnam Zartoshtimanesh
Affiliation:
Department of Preventive and Restorative Dental Sciences
Mehdi Balooch
Affiliation:
Department of Preventive and Restorative Dental Sciences
Sally J. Marshall
Affiliation:
Department of Preventive and Restorative Dental Sciences
Grayson W. Marshall
Affiliation:
Department of Preventive and Restorative Dental Sciences
Pamela K. DenBesten
Affiliation:
Department of Orofacial Sciences, University of California, 707 Parnassus Ave., San Francisco, CA 94143-0758, USA
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Abstract

Mice are commonly considered the model mammal for many biomedical studies. In this work, mouse and human dentin were compared to specify structural and mechanical differences to establish a baseline for comparison of dental tissues between these species. Atomic force microscopy revealed tubules of about 1.0 to 1.6 μm in diameter as the main structural feature in dentin of both species. Nanoindentation yielded the elastic modulus about 15% lower in murine intertubular dentin while the hardness was almost equal. Dynamic stiffness mapping confirmed the lower elastic properties and also revealed that the peritubular region of increased mineralization around tubules is drastically reduced or maybe absent in murine dentin of this age. This study suggests that structural and mechanical differences need to be considered when murine dentin is used as a model system.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 874: Symposium l – Structure and Mechanical Behavior of Biological Materials , 2005 , L5.18
Copyright
Copyright © Materials Research Society 2005

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