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Specific Interaction of Influenza Virus with Organized Assemblies of Polydiacetylenes

Published online by Cambridge University Press:  15 February 2011

Deborah H. Charych ,
Wayne Spevak ,
Jon O. Nagy  and
Mark D. Bednarski
Deborah H. Charych
Affiliation:
The Center for Advanced Materials, Lawrence Berkeley Laboratory, Berkeley, California 94720
Wayne Spevak
Affiliation:
The Center for Advanced Materials, Lawrence Berkeley Laboratory, Berkeley, California 94720
Jon O. Nagy
Affiliation:
The Center for Advanced Materials, Lawrence Berkeley Laboratory, Berkeley, California 94720
Mark D. Bednarski
Affiliation:
The Center for Advanced Materials, Lawrence Berkeley Laboratory, Berkeley, California 94720
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Abstract

Supramolecular organizates of liposomes and Langmuir-Blodgett (LB) films are described which are capable of specifically binding to pathogens such as influenza virus. The specific interaction is between the hemagglutinin protein of the virus and an α-C-glycoside of sialic acid expressed on the surface of the liposome or LB film. Sialic acidcontaining liposomes were found to inhibit influenza virus infectivity in cell culture, and may provide a basis for new materials which act as therapeutic agents. Sialic acid-containing LB films also specifically bind to the influenza virus. In this case, the conjugated polymer backbone acts as a built-in reporter of the binding event, measurable by a chromatic change in the visible absorption spectrum. These films may provide a basis for new materials which act as direct detectors of binding

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 292: Symposium S – Biomolecular Materials , 1992 , 153
Copyright
Copyright © Materials Research Society 1993

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