Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-27T01:59:32.708Z Has data issue: false hasContentIssue false
  • English
  • Français

The Small Diameter Vascular Graft - A Challenging Biomaterials Problem

Published online by Cambridge University Press:  22 February 2011

Allan S. Hoffman ,
Buddy D. Ratner ,
Andy Garfinkle ,
Thomas A. Horbett ,
Larry O. Reynolds  and
Steven R. Hanson
Allan S. Hoffman
Affiliation:
University of Washington, Center for Bioengineering and Chemical Engineering, Seattle, WA Regional Primate Research Center, Seattle, WA
Buddy D. Ratner
Affiliation:
University of Washington, Center for Bioengineering and Chemical Engineering, Seattle, WA
Andy Garfinkle
Affiliation:
University of Washington, Center for Bioengineering and Chemical Engineering, Seattle, WA
Thomas A. Horbett
Affiliation:
University of Washington, Center for Bioengineering and Chemical Engineering, Seattle, WA
Larry O. Reynolds
Affiliation:
University of Washington, Center for Bioengineering and Chemical Engineering, Seattle, WA
Steven R. Hanson
Affiliation:
Scripps Clinic and Research Foundations, La Jolla, CA
Get access

Abstract

The surface composition of a biomaterial can have an important influence on biologic responses. In this paper we report on a surface treatment using a gas discharge which deposits a thin fluorocarbon polymer coating onto tie surface of a synthetic vascular graft. The surface chemistry of the graft is significantly changed, while there is no measurable change in porosity, compliance or surface topography. Treatments with tetrafluoroethylene (TFE) gas yield dramatic improvements in both thrombo and emboli-resistance of the graft, based on in vitro measurements and ex vivo shunt tests in a baboon.

Keywords

Small diameter vascular graftgas plasma dischargefluoropolymer coatingsbiomaterial surface modification.
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 55: Symposium G – Biomedical Materials , 1985 , 3
Copyright
Copyright © Materials Research Society 1986

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Dardik, H., ed., “Graft Materials in Vascular Surgery,” Year Book Med. Publ., Chicago, (1978).Google Scholar
2. Mortensen, J.D., “Safety and Performance of Currently Available Vascular Prostheses,” ASAIO Journal 4: 125, (1981).Google Scholar
3. Sawyer, P.N., Kaplitt, M.J., eds., “Vascular Grafts,” Appleton-Century-Crofts, New York, (1978).Google Scholar
4. Vascular Prostheses Workshop, sponsored by Devices and Technology Branch, NHLBI, Bethesda, MD. May 14, 1981: NIH Publ. No. 82–1215, (1981).Google Scholar
5. Hoffman, A.S., “Synthetic Polymer Biomaterials - a Review,” in “IUPAC - Macromolecules” (eds. Benoit, H. and Rempp, P.), Pergamon Press, London, p. 321 (1982).CrossRefGoogle Scholar
6. Hoffman, A.S., “Ionizing Radiation and Gas Plasma Discharge Treatments for Preparation of Novel Polymeric Biomaterials,” Adv. in Polme Sci, 57, 141–157, (1984).CrossRefGoogle Scholar
7. Bell, A.T., Hollahan, J.R., eds., “.Techniques and Application of Plasma Chemistry,” John Wiley and Sons, New York, (1974).Google Scholar
8. Yasuda, H., Morosoff, N., “Plasma Polymerization of Tetrafluoroethylene. II. Capacitive Radio Frequency Discharge,” J. Appl. Polym. Sci. 23: 1003, (1979).Google Scholar
9. O'Kane, D.F., Rice, D.W., “Preparation and Characterization of Glow Discharge Fluoropolymer-Type Polymers,” J. Macromol. Sci.-Chem. A10(3): 567, (1976).CrossRefGoogle Scholar
10. Hollahan, J.R., Wydeven, T., Johnson, C.C., “Combination Moisture Resistant and Anti-Reflection Plasma Polymerized Thin Films for Optical Coatings,” App. Opt. 13: 1844, (1974).Google Scholar
11. Clark, C.T., Feast, W.J., Kilcast, D., Musgrave, W.K.R., “Applications of ESCA to Polymer Chemistry. III. Structure and Bonding in Homopolymers of Ethylene and the Fluoroethylenes and Determination of the Compositions of Fluoropolymers,” J. Polym. Sci., Polym. Chem. Ed. 11: 389, (1979).Google Scholar
12. Harker, L.A., Slichter, S.J., Sauvage, L.R., “Platelet Consumption by Arterial Prostheses: The Effects of Endotheialization and Pharmacologic Inhibition of Platelet Function,” Ann. Surg. 186: 594, (1977).CrossRefGoogle Scholar
13. Hanson, S.R., Harker, L.A., Ratner, B.D., Hoffman, A.S., “In Vivo Evaluation of Artificial Surfaces with a Non-human Primate Model of Arterial Thrombosis,” J. Lab. Clin. Med. 95: 289, (1980).Google Scholar
14. Garfinkle, A.M., Hoffman, A.S., Ratner, B.D., Hanson, S.R., “Improved Patency in Small Diameter Dacron Vascular Grafts after a Tetrafluoroethylene Glow Discharge Treatment,” Trans. ASAIO, XXX, 432–439, (1984).Google Scholar
15. Hoffman, A.S., Garfinkle, A.M., Ratner, B.D., “Surface Modification of Small Diameter Dacron Vascular Grafts after a Tetrafluoroethylene Glow Discharge Treatment,” Trans. Soc. for Biomatis., Vol. VII p. 337, Washington DC, (April 1984).Google Scholar
16. Hoffman, A.S., Ratner, B.D., Garfinkle, A.M., Hanson, S.R, “Plasma Gas Discharge Treatment for Improving the Biocompatibility of Biomaterials,” Patent pending.Google Scholar
17. Callow, A.D., Ladig, C.B., O'Donnell, T.F., Gembarowicz, R., Keough, E., Ranberg-Laskaris, K., Valeri, R., “Platelet-Arterial Synthetic Graft Interaction and its Modification,” Arch. Surg. 117: 1447, (1982).CrossRefGoogle Scholar
18. Harker, L.A., Hanson, S.R., “Experimental Arterial Thromboembolism in Baboons,” J. Clin, Invest. 64: 559, (1979).CrossRefGoogle Scholar
19. Hanson, S.R., Harker, L.A., Ratner, B.D., Hoffman, A.S., “Evaluation of Arterial Surfaces Using Baboon Arteriovenous Shunt Model,” in “Biomaterials, 1980” (eds. Winter, G., Gibbons, D., Plenk, H.), John Wiley and Sons, London, pp 519–528, (1982).Google Scholar
20. Hoffman, A.S., Ratner, B.D., Horbett, T.A., Reynolds, L.O., Cho, C.S., Harker, L.A., Hanson, S.R., “Unusual Biological Interactions at Biomaterial Interfaces: Influence of Molecular Surface Character,” “Progress in Artificial Organs; Biomaterials”, Raven Press (1983), p 819–824.Google Scholar
21. Reynolds, L.O., Johnson, C., Ishimaru, A., “Diffuse Reflectance from a Finite Blood Medium – Applications to the Modeling of Fiberoptic Catheters,” J. Appl. Optics 15: 2059, (1976).CrossRefGoogle Scholar
22. Reynolds, L.O., Simon, T., “Size Distribution Measurements of Microaggregates in Stored Whole Blood,” Transfusion 20: 669, (1980).CrossRefGoogle Scholar
23. Reynolds, L.O. Sanchez, R., “Radiative Transport Solution for Microparticulate Sizing,” Proc. 26th Ann. Conf. on Eng. in Medicine and Biol. 25: 66, (1983).Google Scholar
24. Wagner, C.D., “Sensitivity of Detection of the Elements by Photoelectron Spectrometry,” Anal. Chem. 44: 1050, (1972).Google Scholar
25. Weathersby, P.K., Horbett, T.A., Hoffman, A.S., “Solution Stability of Bovine Fibrinogen” Thrombosis Research, 10, 245–252, (1977).CrossRefGoogle Scholar
26. Horbett, T.A., “Adsorption of Proteins from Plasma to a Series of Hydrophilic-Hydrophobic Copolymers. II. Compositional Analysis with the Prelabeled Protein Technique,” J. Biomed. Mat. Res. 15, 673–695, (1981).Google Scholar
27. Ratnoff, O.D., Menzie, C., “A New Method for the Determination of Fibrinogen in Small Samples of Plasma,” J. Lab. Clin. Med. 37, 316, (1950).Google Scholar
28. Zisman, W.A., “Influence of Constitution on Adhesion,” Ind. and Eng. Chem. 55: 19, (1969).Google Scholar
29. Yasuda, H., Guziki, M., “Biomedical Applications of Plasma Polymerization and Plasma Treatment of Polymer Surfaces,” Biomaterials, 3, 68–77, (1982).Google Scholar
30. Didisheim, P., Tirrell, M.V., Lyons, C.S., Stropp, J.Q., Dewanjee, M.K. “Relative Role of Surface Chemistry and Surface Texture in Blood-Material Interactions,” Trans. ASAIO 29: 169, (1983).Google Scholar