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Small Diameter, High Surface Energy Carbon Nanofiber Formulations that Selectively Increase Osteoblast Function

Published online by Cambridge University Press:  17 March 2011

Rachel L. Price ,
Kathy L. Elias ,
Karen M. Haberstroh  and
Thomas J. Webster
Rachel L. Price
Affiliation:
Purdue University, Department of Biomedical Engineering West Lafayette, IN 47907-1296, U.S.A.
Kathy L. Elias
Affiliation:
Purdue University, Department of Biomedical Engineering West Lafayette, IN 47907-1296, U.S.A.
Karen M. Haberstroh
Affiliation:
Purdue University, Department of Biomedical Engineering West Lafayette, IN 47907-1296, U.S.A.
Thomas J. Webster
Affiliation:
Purdue University, Department of Biomedical Engineering West Lafayette, IN 47907-1296, U.S.A.
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Abstract

The objective of the present in vitro study was to investigate the potential of carbon nanofibers, which have nanometer dimensions similar to hydroxyapatite crystals in physiological bone, for orthopedic applications. Studies of alkaline phosphatase activity and calcium deposition by osteoblasts (the bone-synthesizing cells) were performed on both nanophase (less than 100 nm) and conventional (greater than 100 nm) diameter carbon nanofibers. Results provided the first evidence of a strong correlation between decreased carbon fiber diameter and both increased alkaline phosphatase activity and increased calcium deposition by osteoblasts at early time points (specifically, 7 days), but not at later time points (specifically, 14 and 21 days). Results of early calcium deposition by osteoblasts on carbon nanofibers are promising and consistent with the desired rapid formation of natural bone at the implant interface.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 711: Symposia FF/GG/HH – Advanced Biomaterials--Characterization, Tissue Engineering and Complexity , 2001 , HH3.11.1
Copyright
Copyright © Materials Research Society 2002

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References

REFERENCES

1. Price, R. L., Kennel, E. B., Haberstroh, K. M.; Webster, T. J., “Bone Cell Adhesion on Carbon Nanofiber Compacts,” submitted to Biomaterials, 2001.Google Scholar
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