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Silicon as an Active Biomaterial

Published online by Cambridge University Press:  15 February 2011

L. T. Canham ,
C. L. Reeves ,
D. J. Wallis ,
J. P. Newey ,
M. R. Houlton ,
G. J. Sapsford ,
R. E. Godfrey ,
A. Loni ,
A. J. Simons  and
T. I. Cox
...Show all authors
L. T. Canham
Affiliation:
DRAMalvern, St Andrews Road, Malvern, Worcestershire. WR14 3PS, UK.
C. L. Reeves
Affiliation:
DRAMalvern, St Andrews Road, Malvern, Worcestershire. WR14 3PS, UK.
D. J. Wallis
Affiliation:
DRAMalvern, St Andrews Road, Malvern, Worcestershire. WR14 3PS, UK.
J. P. Newey
Affiliation:
DRAMalvern, St Andrews Road, Malvern, Worcestershire. WR14 3PS, UK.
M. R. Houlton
Affiliation:
DRAMalvern, St Andrews Road, Malvern, Worcestershire. WR14 3PS, UK.
G. J. Sapsford
Affiliation:
DRAMalvern, St Andrews Road, Malvern, Worcestershire. WR14 3PS, UK.
R. E. Godfrey
Affiliation:
DRAMalvern, St Andrews Road, Malvern, Worcestershire. WR14 3PS, UK.
A. Loni
Affiliation:
DRAMalvern, St Andrews Road, Malvern, Worcestershire. WR14 3PS, UK.
A. J. Simons
Affiliation:
DRAMalvern, St Andrews Road, Malvern, Worcestershire. WR14 3PS, UK.
T. I. Cox
Affiliation:
DRAMalvern, St Andrews Road, Malvern, Worcestershire. WR14 3PS, UK.
M. C. L. Ward
Affiliation:
DRAMalvern, St Andrews Road, Malvern, Worcestershire. WR14 3PS, UK.
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Abstract

The response of a range of porous Si and poly Si films to storage in acellular simulated body fluids is summarised and its implications discussed. It is suggested that the combination of VLSI technology, micromachining and surface microstructuring achievable with silicon, could establish this prominent semiconductor as a very useful biomaterial by the next century. The ‘biocompatibility’ of a variety of silicon microstructures, and even bulk silicon has received surprisingly little study, but now warrants detailed in-vitro and in-vivo assessment.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 452 , 1996 , 579
Copyright
Copyright © Materials Research Society 1997

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References

REFERENCES

[1]da Silva, J.R.F. and Williams, R.J.P.. The Biological Chemistry of the Elements. Clavendon Press, Oxford (1991).Google Scholar
[2]Carlisle, E.M.. Science 178, 619 (1972).Google Scholar
[3]Carlisle, E.M. in Silicon and Siliceous Structures in Biological Systems, edited by Simpson, T.L. and Volcani, B.E.. Springer Verlag (1981), Chapter 4.Google Scholar
[4]Bellia, J.P., Newton, K., Davenport, A., Birchall, J.D., Roberts, N.B.. Eur. J. Clin. Investig. 24, 703 (1994).Google Scholar
[5]Birchall, J.D.. Chem. Soc. Rev. 24, 351 (1995).Google Scholar
[6]Canham, L.T.. Adv. Mater. 7, 1033 (1995).Google Scholar
[7]Canham, L.T., Reeves, C.L. in Thin Films and Surfaces for Bioactivity and Biomedicai Applications edited by Cotell, C.M., Gobatkin, S.M., Grobe, G., Meyer, A.E.. MRS Proc Vol 414, 189 (1996).Google Scholar
[8]Canham, L.T., Newey, J.P., Reeves, C.L., Houlton, M.R., Loni, A., Simons, A.J., Cox, T.I.. Adv Mater. 8, 847 (1996).Google Scholar
[9]Canham, L.T., Reeves, C.L., King, D.O., Branfield, P.J., Crabb, J.G., Ward, M.C.L.. Adv. Mater. 8, 850 (1996).Google Scholar
[10]Sanders, R.S., Lee, M.T.. Proc. IEEE. 84, 480 (1996).Google Scholar
[11]Wang, G., Vannier, M.W., Skinner, M.W., Kalender, W.A., Polacin, A., Ketten, D.R.. IEEE Trans. BME. 43, 891 (1996).Google Scholar
[12]North, R.B., Kidd, D.H., Zahvrak, M., James, C.S., Long, D.M.. Neurosurgery 32, 384 (1993).Google Scholar
[13]Kanoff, R.B.. J.A.O.A. 94, 487 (1994).Google Scholar
[14]Wyatt, J., Rizzo, J.. IEEE Spectrum May (1996) 47.Google Scholar
[15]Chav, H., Wise, K.D.. IEEE Trans. Electron. Devices 35, 2355 (1988).Google Scholar
[16]McKeen, B.D., Gough, D.A.. IEEE Trans. BME. 35, 526 (1988).Google Scholar
[17]Ko, W.H.. IEEE Trans. BME. 33, 153 (1986).Google Scholar
[18]Wise, K.D., Najafi, K.J. in VLSI in Medicine. Edited by Einsprich, N.G. and Gold, R.D.. Acad. Press Inc (1989) Chapter 10.Google Scholar
[19]Erickson, K.A., Wilding, P.. Clin Chem. 39, 283 (1993).Google Scholar
[20]Jacobson, S., Ramsey, J.M.. Anal. Chem. 68, 720 (1996).Google Scholar
[21]Washizu, M., Nanba, T., Masuda, S.. IEEE Trans. Ind. Applic. 26, 352 (1990).Google Scholar
[22]Klein, C.P.A.T., Wolfe, J.G.C., de Groot, K. in An Introduction to Bioceramics Edited by Hench, L.L., Wilson, J.. World Scientific Publ (1993) Chapter 11.Google Scholar
[23]Lacefield, W.R.. in An Introduction to Bioceramics Edited by Hench, L.L., Wilson, J.. World Scientific Publ (1993) Chapter 12.Google Scholar
[24]Hench, L.L.. J. Am. Ceram. Soc 74, 1487 (1992).Google Scholar
[25]Kokubo, T., Kushitani, H., Sakka, S., Kitsugi, T., Yamamuro, T.. J. Biomed. Mater. Res. 24, 721 (1990).Google Scholar
[26]Kokubo, T., Kushitani, H., Ohtsuki, C., Sakka, S., Yamamuro, T.. J. Mat. Sci. Mat. in Medic. 3, 79 (1992).Google Scholar
[27]Li, P., Kangasniemi, I., de Groot, K., Kokubo, T.. J. Am. Ceram. Soc. 77, 1307 (1994).Google Scholar
[28]Kanda, Y., Aoshima, R., Takada, A.. Electron. Lett. 17, 558 (1981).Google Scholar
[29]Edell, D.J., Toi, V.V., McNeil, V.M., Clark, L.D.. IEEE Trans. BME. 39, 635 (1992).Google Scholar
[30]Schmitt, S., Horch, K., Normann, R.. J. Biomed. Mater. Res. 27, 1393 (1993).Google Scholar
[31]Pope, E.J.A.. J. Sol. Gel. Sci. Techn. 4, 225 (1995).Google Scholar
[32]Richter, E., Fuhr, G., Muller, T., Shirley, S., Rogaschewski, S., Reimer, K., Dell, C.. J. Mat. Sci. Mat. in Medic. 7, 85 (1996).Google Scholar