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Self-Assembly of Tyrocidines in Nanotubular Structures

Published online by Cambridge University Press:  15 February 2011

M. Thies  and
H. H. Paradies
M. Thies
Affiliation:
Biotechnology & Physical Chemistry, Mirkische Fachhochschule, Iserlohn, D-58644 Germany, [email protected]
H. H. Paradies
Affiliation:
Biotechnology & Physical Chemistry, Mirkische Fachhochschule, Iserlohn, D-58644 Germany, [email protected] University of Paderbom, Fachbereich Chemie & Chemietechnik, Paderborn, D-33095, Germany.
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Abstract

Hollow tubular structures of tyrocidines, a cyclic decapeptide with two amino acids residues in the D-configuration and eight in the L-configuration, were formed in acid aqueous solutions in the presence of ethanol (20°C). Discrete nanotubes can be produced under controlled conditions, e.g. the amount of water added, or in the presence of protons from ethanol-water solutions (45/55 %v/v). These cyclic oligopeptides crystallize into tubular structures hundreds of nanometer long with an internal diameter of 9.0 Å and outer diameter of 35 Å. Support for the proposed tubular structure is provided by electronmicroscopy, SAXS and Fourier-transform infrared spectroscopy. These structures are open-ended, having a uniform shape and constant internal diameter.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 489: Symposium K – Materials Science of the Cell , 1997 , 145
Copyright
Copyright © Materials Research Society 1998

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