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Self-Assembling Functionalized Amino Acids into Unusual Shapes

Published online by Cambridge University Press:  01 February 2011

Justin R. Barone ,
Naresh K. Budhavaram  and
Katherine J. Harvey
Justin R. Barone
Affiliation:
Biological Systems Engineering Dept., Virginia Tech, 303 Seitz Hall (0303), Blacksburg, VA 24061, U.S.A.
Naresh K. Budhavaram
Affiliation:
Biological Systems Engineering Dept., Virginia Tech, 303 Seitz Hall (0303), Blacksburg, VA 24061, U.S.A.
Katherine J. Harvey
Affiliation:
Biological Systems Engineering Dept., Virginia Tech, 303 Seitz Hall (0303), Blacksburg, VA 24061, U.S.A.
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Abstract

Multi-component small molecule systems that are amphiphilic or that can hydrogen bond end-to-end or side-to-side have been shown to self-assemble into a variety of shapes including fibers, rods, sheets, plates, spheres, and tubes. Recently, we have identified a simple route to self-assemble the same shapes from one-component systems. The structures form by attaching ethyl vinyl sulfone (EVS) to amino acids in water at room temperature. Choice of amino acid, amount of EVS substitution, and solvent conditions determine the final shape. Functionalized amino acids spontaneously form structures like fibers, spheres, tubes, and donuts when dried from solution. Here we focus on fibers and tubes.

Keywords

biomaterialchemical substitutionself-assembly
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1312: Symposium HH/II/JJ – Polymer-Based Materials and Composites—Synthesis, Assembly and Applications , 2011 , mrsf10-1312-jj02-09
Copyright
Copyright © Materials Research Society 2011

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