Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-25T15:30:57.627Z Has data issue: false hasContentIssue false
  • English
  • Français

Radiolabelling of TiO2 Nanoparticle Libraries for Toxicological Investigations

Published online by Cambridge University Press:  31 January 2011

Anthony W. Musumeci ,
Lawrence R Gahan ,
Tijana Rajh ,
Darren J Martin  and
Suzanne V Smith
Anthony W. Musumeci
Affiliation:
[email protected], The University of Queensland, Australian Institute for Bioengineering and Nanotechnology, Brisbane, Queensland, Australia
Lawrence R Gahan
Affiliation:
[email protected], The University of Queensland, School of Molecular and Micorbial Sciences, Brisbane, Queensland, Australia
Tijana Rajh
Affiliation:
[email protected], Argonne Nantional Labs, Center for Nanoscale Materials, Argonne, Illinois, United States
Darren J Martin
Affiliation:
[email protected], The University of Queensland, Australian Institute for Bioengineering and Nanotechnology, Brisbane, Queensland, Australia
Suzanne V Smith
Affiliation:
[email protected], Australian Nuclear Science and Technology Organisation, Institute for Materials Engineering, Lucas Heights, New South Wales, Australia
Get access

Abstract

To further our understanding of nanoparticle interactions with biological systems, it is important that highly sensitive, reliable and robust methods for labelling particles are established. We report here the application of a series of bi-functional cage ligands to radiolabel a range (i.e. shapes and sizes) of titanium dioxide (TiO2) particles. The cages were covalently attached to the surface of the particles via the use of a dopac derivative and then radiolabelled with a gamma emitting radioisotope. The final radiolabelled nanoparticles proved to be stable in solution and the method easy and robust. The application of a gamma emitter allows the radiolabelled particles to be tracked in vivo and in the environment.

Keywords

nanostructuresurface chemistrynanoscale
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1209: Symposia P/YY – Business and Safety Issues in the Commercialization of Nanotechnology , 2009 , 1209-YY04-01
Copyright
Copyright © Materials Research Society 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Rajh, T., et al., Surface Restructuring of Nanoparticles: An Efficient Route for Ligandâ̂'Metal Oxide Crosstalk. The Journal of Physical Chemistry B, 2002. 106(41): p. 10543–10552.Google Scholar
2 Bartolo, N.M.D., et al., Synthesis of a new cage ligand, SarAr, and its complexation with selected transition metal ions for potential use in radioimaging. Journal of the Chemical Society, Dalton Transactions, 2001(15): p. 2303–2309.Google Scholar
3 Morgan, D.L., et al., Determination of a Morphological Phase Diagram of Titania/Titanate Nanostructures from Alkaline Hydrothermal Treatment of Degussa P25. Chemistry of Materials, 2008. 20(12): p. 3800–3802.Google Scholar
4 Rabatic, B.M., et al., Spatially Confined Corner Defects Induce Chemical Functionality of TiO2 Nanorods. Advanced Materials, 2006. 18(8): p. 1033–1037.Google Scholar
5 Rajh, T., Saponijic, Z.V., and Micic, O.I., Reactions of Hydrous Titanium Oxide Colloids with Strong Oxidising Agents. Langmuir, 1992. 8: p. 1265–1270.Google Scholar
6 Thompson, R.C., Oxidation of peroxotitanium(IV) by chlorine and cerium(IV) in acidic perchlorate solution. Inorganic Chemistry, 2002. 23(13): p. 1794–1798.Google Scholar
7 Bodnarchuk, M.I., et al., Photoinduced Electron Transfer between CdS and CdTe Nanoparticles in Colloidal Solutions. Theoretical and Experimental Chemistry, 2004. 40(5): p. 287–292.Google Scholar