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Quantitative Histology and Mechanical Testing of a Biodegradable Bone Cement

Published online by Cambridge University Press:  26 February 2011

Tobin N. Gerhart ,
A. A. Renshaw  and
W. C. Hayes
Tobin N. Gerhart
Affiliation:
Beth Israel Hospital and Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215
A. A. Renshaw
Affiliation:
Beth Israel Hospital and Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215
W. C. Hayes
Affiliation:
Beth Israel Hospital and Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215
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Extract

We have developed a particulate composite bone cement consisting of a particulate phase of tricalcium phosphate (TCP) particles bound together by a polymeric matric phase (PPF). This matrix hardens through a free radical polymerization reaction in vivo within several minutes after mixing. The initial mechanical strength of our particulate composite bone cement results from the matrix, but over time this degrades and the strength is augmented by bone ingrowth and incorporation of the tricalcium phosphate particles. Possible orthopaedic applications include fixation of fractures, augmenting fixation of implants in osteoporetic bone, and temporary stabilization of bone ingrowth prostheses.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 229
Copyright
Copyright © Materials Research Society 1988

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References

1. Urist, M., Fundamental and Clinical Bone Physiology (Lippincott, 1980) pp331–68.Google Scholar
2. Carter, D.R. and Hayes, W.C., Science 194, 1174–6 (1976).Google Scholar