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Pulsed-DC Electrospray for Biopolymer Particle Production

Published online by Cambridge University Press:  31 January 2011

Cho-Hui Lim ,
Kiersten R Schierbeek  and
Michael E Mullins
Cho-Hui Lim
Affiliation:
[email protected], Michigan Technological University, Chemical Engineering, Houghton, Michigan, United States
Kiersten R Schierbeek
Affiliation:
[email protected], Michigan Technological University, Biological Sciences, Houghton, Michigan, United States
Michael E Mullins
Affiliation:
[email protected], Michigan Technological University, Chemical Engineering, Houghton, Michigan, United States
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Abstract

PLLA microparticles were successfully fabricated via pulsed-DC electrospray. In this study, we investigated the effect of the pulsed voltage characteristics (e.g. pulse frequency, pulse amplitude and pulse width) on the particle’s size. We found that pulse frequency, pulse amplitude, pulse width, and the combinations of these factors had a statistically significant effect on the particle’s size. The process conditions to obtain smaller particles with uniform shape and size are a low pulse frequency, high pulse amplitude, and long pulse width (or a high duty cycle).

Keywords

biomaterialpolymerspray-drying
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1239: Symposium VV – Micro- and Nanoscale Processing of Biomaterials , 2009 , 1239-VV07-21
Copyright
Copyright © Materials Research Society 2010

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References

1 Astete, C. E. and Sabliov, C. M. Journal of Biomaterials Science, Polymer Edition 17 (3), 247–289 (2006).Google Scholar
2 Kumar, M. N. V. Ravi, Kumar, N. Domb, A. J. and Arora, M. Advances in Polymer Science 160, 45–117 (2002).Google Scholar
3 Solaro, R. in China-EU forum on Nanosized Technology (China, 2002), pp. 225–244.Google Scholar
4 Alonso, M. J. in Microparticulate Systems for the Delivery of Proteins and Vaccines edited by Cohen, S. and Bernstein, H. (Marcel Dekker, Inc., NY, 1996), Vol. 77, pp. 203–242.Google Scholar
5 Barratt, G. M. Pharmaceutical Science & Technology Today 3 (5), 163–171 (2000).Google Scholar
6 Yeo, L. Y. and Chang, H.C. WIT Transactions on Engineering Sciences: Advances in Fluid Mechanics VI 52, 223–231 (2006).Google Scholar
7 Yeo, L. Y. Gagnon, Z. and Chang, H.C. Biomaterials 26 (31), 6122–6128 (2005).Google Scholar
8 Taylor, G. Proceedings of the Royal Society of London. Series A, Mathematical and Physical Sciences 280 (1382), 383–397 (1964).Google Scholar