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Properties and Applications of Novel DNA-Based Surfactants

Published online by Cambridge University Press:  01 February 2011

Vesselin N. Paunov ,
Chun Xu ,
Pietro Taylor ,
Mustafa Ersoz  and
Paul D.I. Fletcher
Vesselin N. Paunov
Affiliation:
Department of Chemistry, University of Hull, Hull, HU6 7RX, United Kingdom.
Chun Xu
Affiliation:
Department of Chemistry, University of Hull, Hull, HU6 7RX, United Kingdom.
Pietro Taylor
Affiliation:
Department of Chemistry, University of Hull, Hull, HU6 7RX, United Kingdom.
Mustafa Ersoz
Affiliation:
Department of Chemistry, University of Hull, Hull, HU6 7RX, United Kingdom.
Paul D.I. Fletcher
Affiliation:
Department of Chemistry, University of Hull, Hull, HU6 7RX, United Kingdom.
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Abstract

We have designed a novel class of functional surfactants based on DNA and have explored their properties in relation to several possible applications. The DNA-surfactants consist of short chain DNA oligonucleotides covalently bound to a large hydrophobic group, which makes the DNA molecules amphiphilic. We demonstrate that these materials behave like common detergents and are surface-active at various fluid surfaces, e.g. air-water, oil-water interfaces, and lipid bilayers. We also show that once adsorbed the DNA-surfactants remain on the liquid surface upon hybridisation with a complementary DNA chain. We use complementary DNA-surfactants to functionalise fluid surfaces and to program the interactions between them based on Watson-Crick pairing. By selecting the appropriate DNA base sequences, the interaction between the fluid surfaces functionalised with DNA-surfactants can be programmed with a very high specificity. We have also developed a novel procedure for micro-patterning of solid surfaces with DNA by a microcontact printing with aqueous inks of DNA-surfactants which can be utilised for rapid fabrication of DNA assays and genetic biochips.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 845: Symposium AA – Nanoscale Materials Science in Biology and Medicine , 2004 , AA6.4
Copyright
Copyright © Materials Research Society 2005

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References

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