Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-25T15:24:32.109Z Has data issue: false hasContentIssue false
  • English
  • Français

Preparation of Nanoparticle-containing Aligned Collagen Fibers for Dense Connective Tissue Repair and Regeneration

Published online by Cambridge University Press:  19 April 2012

Xingguo Cheng  and
Sapna A. Desai
Xingguo Cheng
Affiliation:
Microencapsulation and Nanomaterials Department, Southwest Research Institute, 6220 Culebra Rd, San Antonio, TX 78238, U.S.A.
Sapna A. Desai
Affiliation:
Microencapsulation and Nanomaterials Department, Southwest Research Institute, 6220 Culebra Rd, San Antonio, TX 78238, U.S.A.
Get access

Abstract

Nanoparticles (NPs) loaded with human platelet-derived growth factor (h-PDGF) were prepared and characterized. These NPs were co-assembled with collagen to form highly aligned NP-collagen composite fibers by using an electrochemical process. PDGF can be released gradually from either NPs or aligned NP-collagen fibers. This investigation demonstrated a novel way to fabricate highly aligned composite fibers, which can locally release a growth factor in a controlled and gradual manner, potentially avoiding the fast clearance of the growth factor from the implantation site. Thus, the aligned NP-collagen fiber is a novel and promising implantation material for tendon/ligament repair and regeneration.

Keywords

fibertissuebiomimetic (assembly)
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1417: Symposium KK – Biomaterials for Tissue Regeneration , 2012 , mrsf11-1417-kk03-10
Copyright
Copyright © Materials Research Society 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Chen, J. M., Xu, J. K., Wang, A. L. and Zheng, M. H., ‘Scaffolds for tendon and ligament repair: review of the efficacy of commercial products’, Expert Review of Medical Devices 6/1 (2009), 61–73.Google Scholar
2. Ge, Z. G., Yang, F., Goh, J. C. H., Ramakrishna, S. and Lee, E. H., ‘Biomaterials and scaffolds for ligament tissue engineering’, Journal of Biomedical Materials Research Part A 77A/3 (2006), 639–652.Google Scholar
3. Cheng, X. G., Gurkan, U. A., Dehen, C. J., Tate, M. P., Hillhouse, H. W., Simpson, G. J. and Akkus, O., ‘An electrochemical fabrication process for the assembly of anisotropically oriented collagen bundles’, Biomaterials 29/22 (2008), 3278–3288.Google Scholar
4. Cheng, X. G. and Rossini, G, ‘Bone-targeting Nanoparticles: Synthesis, Biodistribution and In-vitro Efficacy, 56th ORS conference’, (New Orleans, LA, 2010).Google Scholar
5. Wei, G. B., Jin, Q. M., Giannobile, W. V. and Ma, P. X., ‘Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB’, Journal of Controlled Release 112/1 (2006), 103–110.Google Scholar
6. Dainiak, N., Davies, G., Kalmanti, M., Lawler, J. and Kulkarni, V., ‘Platelet-derived growth factor promotes proliferation of erythropoietic progenitor cells in vitro ’, Journal of Clinical Investigation 71/5 (1983), 1206–1214.Google Scholar