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Preparation of Nanoparticle-containing Aligned Collagen Fibers for Dense Connective Tissue Repair and Regeneration

Published online by Cambridge University Press:  19 April 2012

Xingguo Cheng  and
Sapna A. Desai
Xingguo Cheng
Affiliation:
Microencapsulation and Nanomaterials Department, Southwest Research Institute, 6220 Culebra Rd, San Antonio, TX 78238, U.S.A.
Sapna A. Desai
Affiliation:
Microencapsulation and Nanomaterials Department, Southwest Research Institute, 6220 Culebra Rd, San Antonio, TX 78238, U.S.A.
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Abstract

Nanoparticles (NPs) loaded with human platelet-derived growth factor (h-PDGF) were prepared and characterized. These NPs were co-assembled with collagen to form highly aligned NP-collagen composite fibers by using an electrochemical process. PDGF can be released gradually from either NPs or aligned NP-collagen fibers. This investigation demonstrated a novel way to fabricate highly aligned composite fibers, which can locally release a growth factor in a controlled and gradual manner, potentially avoiding the fast clearance of the growth factor from the implantation site. Thus, the aligned NP-collagen fiber is a novel and promising implantation material for tendon/ligament repair and regeneration.

Keywords

fibertissuebiomimetic (assembly)
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1417: Symposium KK – Biomaterials for Tissue Regeneration , 2012 , mrsf11-1417-kk03-10
Copyright
Copyright © Materials Research Society 2012

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References

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