Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-27T02:23:40.840Z Has data issue: false hasContentIssue false
  • English
  • Français

Porous Composites for Adhering Artificial Cartilage to Bone

Published online by Cambridge University Press:  17 March 2011

Kai Zhang ,
Mary E. Grimm ,
Qiwei Lu ,
Theodore R. Oegema Jr  and
Lorraine F. Francis
Kai Zhang
Affiliation:
Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA
Mary E. Grimm
Affiliation:
Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA
Qiwei Lu
Affiliation:
Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA
Theodore R. Oegema Jr
Affiliation:
Departments of Orthopaedic Surgery and Biochemistry, University of Minnesota, Minneapolis, MN 55455, USA
Lorraine F. Francis
Affiliation:
Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA
Get access

Abstract

Artificial cartilage can be grown from cultured chondrocytes, but adhering this tissue to bone presents a challenge. Porous polymer/bioactive glass composites are candidate materials for engineering the artificial cartilage/bone interface and possibly other soft-to-hard tissue (ligament/bone, tendon/bone) interfaces. A phase separation technique was used to make porous polymer/bioactive glass composites. The composites (thickness: 200-500 μm) have asymmetric structures with dense top layers and porous structures beneath. The porous structures consist of large pores (>100 μm) in a network of smaller (<10 μm) interconnected pores. The dense layers were removed and large pores exposed by abrasion or salt leaching from the casting surface. The tissue bonding abilities of the composites were studied in vitro in simulated body fluid (SBF) and in rabbit chondrocyte culture. Culture studies revealed that composite surfaces were suitable for attachment, spreading and proliferation of chondrocytes. The growth of hydroxycarbonate apatite (HCA) inside and on the composites after soaking in the SBF for two weeks demonstrates their potential for integration with bone. The results indicate the potential for the composites to facilitate growth and attachment of artificial cartilage to bone.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 711: Symposia FF/GG/HH – Advanced Biomaterials--Characterization, Tissue Engineering and Complexity , 2001 , GG4.2.1
Copyright
Copyright © Materials Research Society 2002

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Fedewa, M. M., Oegema, T. R. Jr, Schwartz, M. H., MacLeod, A., Lewis, J. L., Journal of Orthopedics Research 16, 227 (1998).Google Scholar
2. Oegema, T. R. Jr, Carpenter, R. J.., Hofmeister, R. Jr, Thompson, C., Microscopy Research and Technique 37, 324 (1997).Google Scholar
3. Hench, L. L., J.Am.Ceram.Soc. 81, 1705 (1998).Google Scholar
4. Ignjatovic, N., Tomic, S., Dakic, M, Miljkovic, M, Plavsic, M, Uskokovic, D., Biomaterials 20, 809–816 (1999).Google Scholar
5. Pesek, S. C. and Koros, W. J., J. Membrane Sci. 81, 71 (1993).Google Scholar
6. Zhang, K., Ma, Y., Francis, L. F., J. Biomed. Mater. Res. accepted, (2002).Google Scholar
7. Kokubo, T., Kushitani, H., Ohtsuki, C., Sakka, S., Yamamuro, T., J. Mater. Sci.: Materials in Medicine 1, 233 (1990).Google Scholar
8. Androff, N. M., Francis, L. F., Velamakanni, B. V., AIChE Journal 43, 2878 (1997).Google Scholar
9. Grimm, M. E., Francis, L. F., Lewis, J. L., Oegema, T. R. Jr Connective Tissue Research submitted, (2001).Google Scholar
10. Kokubo, T., Kushitani, H., Sakka, S., Kitugi, T., Yamanuro, T.. J. Biomed. Mater. Res. 24, 721 (1990).Google Scholar