Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-27T02:04:17.658Z Has data issue: false hasContentIssue false
  • English
  • Français

Polymers for Forming Drug-Loaded Microspheres: Natural Versus Synthetic

Published online by Cambridge University Press:  21 February 2011

Curt Thies
Curt Thies*
Affiliation:
Biological Transport Laboratory, Washington University, St. Louis, MO 63130
Get access

Extract

Numerous research groups currently are working to develop microcapsules, microspheres, and nanoparticles able to function as effective drug carriers. Much effort is focused on forming biodegradable particles from iactide-glycolide copolymers (PLGA)1−3. Although microparticles prepared from PLGA copolymers have had many successes, PLGA copolymers are not ideal drug carriers. Many other materials conceptually could be formed into suitable particulate drug carriers: synthetic polymers other than PLGA, natural polymers, chemical derivatives of natural polymers, selected inorganics, and nonpolymeric lipids. The purpose of this paper is not to discuss the advantages and limitations of each of these classes of carrier materials, but to contrast the features of PLGA copolymers with those of potentially competitive natural polymers. PLGA copolymers are used as the reference standard, because they are an approved family of biodegradable drug carrier polymers utilized by many research groups globally.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 394: Symposium Z – Polymers in Medicine and Pharmacy , 1995 , 49
Copyright
Copyright © Materials Research Society 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Lewis, D.H., in Biodegradable Polymers as Drug Delivery Systems, edited by Langer, R. and Chasin, M. (Marcel Dekker, New York, N.Y., 1990), p 1.Google Scholar
2. Holland, S.J. and Tighe, B.J., in Advances in Pharmaceutical Sciences, Vol 6, edited by Ganderton, D. and Jones, J. (Academic Press, New York 1991), p 101.Google Scholar
3. Juni, K. and Nakano, M., Critical Reviews in Therapeutic Drug Carrier Systems, 3, 209 (1987).Google Scholar
4. Lemoine, D., Francois, C., Kedzierewicz, F., Maincent, P., Hoffman, M., and Preat, V., IX emes Journees Scientifiques du G.T.R.V., Paris, France, Decembre 8–9, 1994.Google Scholar
5. Strick, L.C.E., in Failure of Plastics, edited by Brostow, W. and Comeliussen, R.D. (Hanser Publishers, New York, 1986), p 209.Google Scholar
6. Sinko, C.M., Yee, A.F., and Amidon, G.L., Proceed. Intern. Syrup. Control. Rel. Bioact. Mater. 16, 467 (1989).Google Scholar
7. Cavalier, M., Benoit, J.P., and Thies, C., J. Pharm. Pharmacol. 38, 249 (1985).Google Scholar
8. Benoit, J.P., Courteille, F. and Thies, C., Intl. J. Pharm. 29, 95 (1986).Google Scholar
9. Courteille, F., Benoit, J.P., and Thies, C., J. Control. Rel. 30, 17 (1994).Google Scholar
10. Benita, S., Benoit, J.P., Puisieux, F., and Thies, C., J. Pharm. Sci. 73, 1721 (1984).Google Scholar
11. Bendix, D., Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 17, 248 (1990).Google Scholar
12. Floy, B.J., Visor, G.C., and Sanders, L.M., in Polymeric Delivery Systems, edited by El-Nokaly, M.A., Piatt, D.M., and Charpentier, B.A. (ACS Symposium Series 520, Washington, D.C., 1993), p. 154.Google Scholar
13. Franz, G., in Advances in Polymer Science, edited by Dusek, K. (Springer-Verlag, Berlin, 1986), p. 1.Google Scholar
14. Thies, C., in Controlled Release of Drugs: Polymers and Aggregate Systems, edited by Rosoff, M.(VCH Publishers, New York, 1989), p. 97.Google Scholar