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Poly(α-Hydroxy Ester)/Short Fiber Hydroxyapatite Composite Foams for Orthopedic Application

Published online by Cambridge University Press:  21 February 2011

Robert C. Thomson ,
Michael J. Yaszemski ,
John M. Powers ,
Timothy P. Harrigan  and
Antonios G. Mikos
Robert C. Thomson
Affiliation:
Institute of Biosciences and Bioengineering, Rice University, Houston, TX
Michael J. Yaszemski
Affiliation:
Department of Orthopaedic Surgery, Wilford Hall Medical Center, Lackland AFB, TX
John M. Powers
Affiliation:
Department of Oral Biomaterials, University of Texas Health Science Center at Houston, Houston, TX
Timothy P. Harrigan
Affiliation:
Department of Orthopaedic Surgery, University of Texas Health Science Center at Houston, Houston, TX
Antonios G. Mikos
Affiliation:
Institute of Biosciences and Bioengineering, Rice University, Houston, TX
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Abstract

A process has been developed to manufacture biodegradable composite foams of poly(DL-lactic- co-glycolic acid) (PLGA) and hydroxyapatite short fibers for use in bone regeneration. The processing technique allows the manufacture of three-dimensional foam scaffolds and involves the formation of a composite material consisting of a porogen material (either gelatin microspheres or salt particles) and hydroxyapatite short fibers embedded in a PLGA matrix. After the porogen is leached out, an open-cell composite foam remains which has a pore size and morphology defined by the porogen. The foam porosity can be controlled by altering the volume fraction of porogen used to make the composite material. Foams made using NaCl particles as a porogen were manufactured with porosities as high as 0.84±0.01 (n=3). The short hydroxyapatite fibers served to reinforce the PLGA. The compressive yield strength of foams manufactured using gelatin microspheres as a porogen was found to increase with fiber content. Foams with compressive yield strengths up to 2.82±0.63 MPa (n=3) with porosities of 0.47±0.01 (n=3) were manufactured using 30% by weight hydroxyapatite fibers in the initial composite prior to leaching. These composite foams with improved mechanical properties may also be expected to have enhanced osteoconductivity and hence provide a novel material which may prove useful in the field of bone regeneration.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 394: Symposium Z – Polymers in Medicine and Pharmacy , 1995 , 25
Copyright
Copyright © Materials Research Society 1995

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References

1. Schmitz, J.P. and Hollinger, J.O., Clin. Orthop. Rel. Res., 237, 245 (1988).Google Scholar
2. Burr, D.B., Mori, S., Boyd, R.D., Sun, T.C., Blaha, J.D., Lane, L., and Parr, J., J. Biomed. Mater. Res., 27, 645 (1993).Google Scholar
3. Jasty, M., Bragdon, C.R., Haire, T., Mulroy, J. , R. D., and Harris, W.H., J. Biomed. Mater. Res., 27, 639 (1993).Google Scholar
4. Toriumi, D.M. and Robertson, K., Facial Plast. Surg., 9, 29 (1993).Google Scholar
5. Habal, M.B., J. Craniofacial Surg., 2, 27 (1991).Google Scholar
6. Ripamonti, U., J. Craniofacial Surg., 3, 149 (1992).Google Scholar
7. Amler, M.H. and LeGeros, R.Z., J. Biomed. Mater. Res., 24, 1079 (1990).Google Scholar
8. Uyama, S., Kaufmann, P.M., Tadeka, T., and Vacanti, J.P., Transplantation, 55, 932 (1993).Google Scholar
9. Freed, L.E., Marquis, J.C., Nohria, A., Emmanual, J., Mikos, A.G., and Langer, R., J. Biomed. Mater. Res., 27, 11 (1993).Google Scholar
10. Atala, A., Vacanti, J.P., Peters, C.A., Mandell, J., Retik, A.B., and Freeman, M.R., J. Urol., 148, 658 (1992).Google Scholar
11. Ishaug, S.L., Yaszemski, M.J., Bizios, R., and Mikos, A.G., J. Biomed. Mater. Res., 28, 1445 (1994).Google Scholar
12. Vert, M., Christel, P., Chabot, F., and Leray, J., in Macromolecular Biomaterials, edited by Hastings, G.W. and Ducheyne, P. (CRC Press, Boca Raton, Florida, 1984), p. 119.Google Scholar
13. Thomson, R.C., Yaszemski, M.J., Powers, J.M., and Mikos, A.G., J. Biomater. Sci., Polym. Ed., 7, 23 (1995).Google Scholar
14. Mikos, A.G., Thorsen, A.J., Czerwonka, L.A., Bao, Y., Langer, R., Winslow, D.N., and Vacanti, J.P., Polymer, 35, 1068 (1994).Google Scholar
15. Goldstein, S.A., J. Biomech., 20, 1055 (1987).Google Scholar