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The Physical Properties of a Hyaluronic Acid Based Bioresorbable Membrane for the Prevention of postsurgical Adhesions

Published online by Cambridge University Press:  15 February 2011

K. Greenawalt ,
L. Masi ,
C. Muir  and
J. Burns
K. Greenawalt
Affiliation:
Biopolymers Department, Genzyme Corporation, Cambridge, MA 02139
L. Masi
Affiliation:
Biopolymers Department, Genzyme Corporation, Cambridge, MA 02139
C. Muir
Affiliation:
Biopolymers Department, Genzyme Corporation, Cambridge, MA 02139
J. Burns
Affiliation:
Biopolymers Department, Genzyme Corporation, Cambridge, MA 02139
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Abstract

We have evaluated the physical properties and animal efficacy of a hyaluronic acid (HA) based bioresorbable membrane for the prevention of post-surgical adhesions. Test methods were developed to measure the dry and wet tensile properties and ia Xilm tissue adhesiveness of the membranes. The thin membranes were found to have sufficient strength and flexibility in the dry state for surgical handling. When hydrated in buffered saline, the membranes became weaker and more elastic. The membranes exhibited a high degree of tissue adhesiveness and significantly reduced adhesion formation in a rat cecal abrasion model.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 292: Symposium S – Biomolecular Materials , 1992 , 265
Copyright
Copyright © Materials Research Society 1993

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