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Percutaneous Biomedical Device with a Regenerative Materials Interface

Published online by Cambridge University Press:  15 March 2011

Antonio Peramo ,
Cynthia L. Marcelo ,
Steve Goldstein  and
David C. Martin
Antonio Peramo
Affiliation:
Department of Materials Science and Engineering, Ann Arbor, MI 48109, U.S.A.
Cynthia L. Marcelo
Affiliation:
Department of Chemical Engineering, Ann Arbor, MI 48109, U.S.A.
Steve Goldstein
Affiliation:
Department of Orthopaedic Surgery Ann Arbor, MI 48109, U.S.A.
David C. Martin
Affiliation:
Department of Materials Science and Engineering, Ann Arbor, MI 48109, U.S.A.
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Abstract

We have developed an in vitro culture system composed of organotypic human skin explants interfaced with titanium rods or stainless steel fixator pins. The use of this interface provides a model to evaluate strategies for creating a stable, long-term connection with living skin and chronic percutaneous devices. Our hypothesis is that the delivery of specific biomaterials at this interface will create a dynamic, slowly flowing matrix for skin biointegration, local administration of drugs or antimicrobials. We define this concept as the generation of an artificial mucosa, because it mimics the situation of several epithelial tissues (like the periodontal junction between the tooth and the junctional epithelium) where antimicrobial peptides and mucins are constantly extruded.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1136: Symposium DD – Materials in Tissue Engineering , 2008 , 1136-DD04-09
Copyright
Copyright © Materials Research Society 2007

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References

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