Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-25T15:45:58.445Z Has data issue: false hasContentIssue false
  • English
  • Français

Percutaneous Biomedical Device with a Regenerative Materials Interface

Published online by Cambridge University Press:  15 March 2011

Antonio Peramo ,
Cynthia L. Marcelo ,
Steve Goldstein  and
David C. Martin
Antonio Peramo
Affiliation:
Department of Materials Science and Engineering, Ann Arbor, MI 48109, U.S.A.
Cynthia L. Marcelo
Affiliation:
Department of Chemical Engineering, Ann Arbor, MI 48109, U.S.A.
Steve Goldstein
Affiliation:
Department of Orthopaedic Surgery Ann Arbor, MI 48109, U.S.A.
David C. Martin
Affiliation:
Department of Materials Science and Engineering, Ann Arbor, MI 48109, U.S.A.
Get access

Abstract

We have developed an in vitro culture system composed of organotypic human skin explants interfaced with titanium rods or stainless steel fixator pins. The use of this interface provides a model to evaluate strategies for creating a stable, long-term connection with living skin and chronic percutaneous devices. Our hypothesis is that the delivery of specific biomaterials at this interface will create a dynamic, slowly flowing matrix for skin biointegration, local administration of drugs or antimicrobials. We define this concept as the generation of an artificial mucosa, because it mimics the situation of several epithelial tissues (like the periodontal junction between the tooth and the junctional epithelium) where antimicrobial peptides and mucins are constantly extruded.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1136: Symposium DD – Materials in Tissue Engineering , 2008 , 1136-DD04-09
Copyright
Copyright © Materials Research Society 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Mahan, J., Seligson, D., Henry, S.L., Hynes, P. and Dobbins, J., Orthopedics 14, 305 (1991).Google Scholar
2. Pickup, J.C., Hussain, F., Evans, N.D. and Sachedina, N., Biosens. Bioelectron. 20, 1897 (2005).Google Scholar
3. Winter, G.D., J. Biomed. Mater. Res. Symp. No. 5 (Part I) 101, 99 (1974).Google Scholar
4. Recum, A.F. Von, J. Biomed. Mater. Res. 18, 323 (1984).Google Scholar
5. Pendergrass, C.J., Goodship, A.E. and Blunn, G.W., Biomaterials 27, 4183 (2006).Google Scholar
6. Campbell, A.A., Song, L., Li, X.S., Nelson, B.J., Bottoni, C., Brooks, D.E., DeJong, E.S., J. Biomed. Mater. Res. (Appl. Biomater.) 53, 400 (2000).Google Scholar
7. Xu, W., Xu, D.H., Crocombe, A.D., Proc. Inst. Mech. Eng. [H] 220, 661 (2006).Google Scholar
8. Peramo, A., Marcelo, C.L., Goldstein, S.A., Martin, D.C.. Annals Biomed. Eng. In Press.Google Scholar
9. Martin, D.C., Peramo, A., Goldstein, S.A.. US Provisional Patent 61/063, 704 (2008).Google Scholar
10. Bedoni, M., Sforza, C., Dolci, C. and Donetti, E., J. Dermatol. Sci. 46, 139 (2007).Google Scholar