Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-25T15:40:04.313Z Has data issue: false hasContentIssue false
  • English
  • Français

Optimising of the Physico-Chemical Properties of a Novel Barium Sulphate Preparation for the X-Ray Examination of the Intestine

Published online by Cambridge University Press:  15 February 2011

Barbara Laermann ,
Paul O'Brien  and
Clive Bartrama
Barbara Laermann
Affiliation:
Department of Chemistry, Imperial College of Science, Technology and Medicine, Exhibition Road, London SW7 2AY, UKEmail: [email protected], [email protected]
Paul O'Brien
Affiliation:
Department of Chemistry, Imperial College of Science, Technology and Medicine, Exhibition Road, London SW7 2AY, UKEmail: [email protected], [email protected]
Clive Bartrama
Affiliation:
Department of Chemistry, Imperial College of Science, Technology and Medicine, Exhibition Road, London SW7 2AY, UKEmail: [email protected], [email protected] St. Mark's Hospital, London, UKEmail: [email protected]
Get access

Abstract

Novel barium sulphate preparations for X-ray contrasting with defined rheological properties have been developed which provide both low viscosity and high density. The relationship between volume fraction and both high-shear and low-shear viscosity was investigated to obtain the relative viscosity [η] and the limiting packing fraction Φm. The particles in a good preparation have a hydrophilic surface which allows the particles to penetrate through the mucus layer of the gastro-intestinal tract. Adsorption isotherms for chondroitin sulphate on barium sulphate from aqueous solution have been determined by spectrophotometry. FTIR spectroscopy and SEM has been used to analyse adsorption behaviour at a molecular level. Coating studies on mouse intestinal mucosa were carried out. A model for testing the coating thickness and particle packing of proprietary and test suspensions was developed. Surface and cross-sections characterisation of a novel test preparation on the intestinal model were determined using cryo scanning electron microscopy. In order to test the resolution obtained with novel material a phantom has been developed.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 550: Symposium GG/HH/II – Biomedical Materials-Drug Delivery, Implants and Tissue Engr , 1998 , 59
Copyright
Copyright © Materials Research Society 1999

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Mitooka, H., Stomach and Intestine (Tokyo) 30, 1491(1995).Google Scholar
2. Neagle, Rochester, Faraday Transaction 85, 429. (1989).Google Scholar
3. Aspland, J. R., Bird, C. L., J. Soc. Dyers Colour 77, 9 (1961).Google Scholar
4. Giles, C. H., D'Silva, P., Easton, I. A., J. Colloid Interface Sci. 47, 766 (1974).Google Scholar
5. Nakamoto, K., Infrared and Raman Spectra of Inorganic and coordination compounds, 4th ed. (Wiley-Interscience publication 1986), pp. 231.Google Scholar
6. Orr, S. F. D., Harris, R. J. C., Sylvdn, B., Nature 169, 544 (1952).Google Scholar
7. Krieger, I. M., Adv Coll and Int Sci 3, 111 (1972).Google Scholar
8. Soppe, W., Powder Techn 62, 189 (1990).Google Scholar