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Optimising of the Physico-Chemical Properties of a Novel Barium Sulphate Preparation for the X-Ray Examination of the Intestine

Published online by Cambridge University Press:  15 February 2011

Barbara Laermann ,
Paul O'Brien  and
Clive Bartrama
Barbara Laermann
Affiliation:
Department of Chemistry, Imperial College of Science, Technology and Medicine, Exhibition Road, London SW7 2AY, UKEmail: [email protected], [email protected]
Paul O'Brien
Affiliation:
Department of Chemistry, Imperial College of Science, Technology and Medicine, Exhibition Road, London SW7 2AY, UKEmail: [email protected], [email protected]
Clive Bartrama
Affiliation:
Department of Chemistry, Imperial College of Science, Technology and Medicine, Exhibition Road, London SW7 2AY, UKEmail: [email protected], [email protected] St. Mark's Hospital, London, UKEmail: [email protected]
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Abstract

Novel barium sulphate preparations for X-ray contrasting with defined rheological properties have been developed which provide both low viscosity and high density. The relationship between volume fraction and both high-shear and low-shear viscosity was investigated to obtain the relative viscosity [η] and the limiting packing fraction Φm. The particles in a good preparation have a hydrophilic surface which allows the particles to penetrate through the mucus layer of the gastro-intestinal tract. Adsorption isotherms for chondroitin sulphate on barium sulphate from aqueous solution have been determined by spectrophotometry. FTIR spectroscopy and SEM has been used to analyse adsorption behaviour at a molecular level. Coating studies on mouse intestinal mucosa were carried out. A model for testing the coating thickness and particle packing of proprietary and test suspensions was developed. Surface and cross-sections characterisation of a novel test preparation on the intestinal model were determined using cryo scanning electron microscopy. In order to test the resolution obtained with novel material a phantom has been developed.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 550: Symposium GG/HH/II – Biomedical Materials-Drug Delivery, Implants and Tissue Engr , 1998 , 59
Copyright
Copyright © Materials Research Society 1999

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