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Novel Preparation of Poly(Vinyl Alcohol) Microparticles without Crosslinking Agent for Controlled Drug Delivery

Published online by Cambridge University Press:  15 February 2011

Becky J. Ficek  and
Nicholas A. Peppas
Becky J. Ficek
Affiliation:
School of Pharmacy, University of London, London, WC1N lAX, England
Nicholas A. Peppas
Affiliation:
School of Chemical Engineering, Purdue University, West Lafayette, IN 47907–1283
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Abstract

Poly(vinyl alcohol) microparticles were prepared by a novel freezing-thawing process in the absence of a crosslinking agent. An aqueous PVA solution to which 1.25 wt% sodium lauryl sulfate was added was dispersed in corn oil. The system was agitated and the ensuing suspended droplets of PVA solution were solidified by a cyclic freezing-thawing process. Key parameters of the process were the PVA to corn oil ratio, the amount of surfactant added, agitation speed, number of freeze cycles, temperatures of freezing and thawing, and presence of additional components.

Crystallization was observed during the freezing-thawing process. The degree of crystallinity was measured with differential scanning calorimetry. Bovine serum albumin was incorporated into the particles by an absorption technique. Studies of BSA release from the microparticles in vitro showed that the release could be prolonged for up to 7 days. BSA diffusion coefficients were calculated from these data and the release mechanism was identified.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 331: Symposium T – Biomaterials for Drug and Cell Delivery , 1993 , 223
Copyright
Copyright © Materials Research Society 1994

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