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Novel Absorbable Polyurethane Biomaterials and Scaffolds for Tissue Engineering

Published online by Cambridge University Press:  04 April 2014

Syam P. Nukavarapu ,
Rao S. Bezwada ,
Deborah L. Dorcemus ,
Neeti Srivasthava  and
Robert J. Armentano
Syam P. Nukavarapu
Affiliation:
Institute for Regenerative Engineering, University of Connecticut Health Center Farmington, CT 06030, U.S.A Biomedical Engineering, University of Connecticut Storrs, CT 06269, U.S.A Materials Science & Engineering, University of Connecticut Storrs, CT 06269, U.S.A Orthopedic Surgery, University of Connecticut Health Center, Farmington, CT 06030, U.S.A
Rao S. Bezwada
Affiliation:
Bezwada Biochemical, LLC., Hillsborough, NJ, US.
Deborah L. Dorcemus
Affiliation:
Institute for Regenerative Engineering, University of Connecticut Health Center Farmington, CT 06030, U.S.A Biomedical Engineering, University of Connecticut Storrs, CT 06269, U.S.A
Neeti Srivasthava
Affiliation:
Bezwada Biochemical, LLC., Hillsborough, NJ, US.
Robert J. Armentano
Affiliation:
Institute for Regenerative Engineering, University of Connecticut Health Center Farmington, CT 06030, U.S.A
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Abstract

This study reports a novel class of biodegradable polyurethane biomaterials and three-dimensional scaffolds for tissue engineering. Solvent casted polyurethane films were studied for biocompatibility by seeding with human bone marrow derived stromal cells. In order to develop a three-dimensional and porous structure, a dynamic solvent sintering method was applied to the polyurethanes for the first time. Microstructural studies on the sintered scaffolds reveal porous structure formation with bonding between the adjacent microspheres. In conclusion, this study establishes new polyurethane biomaterials that are fully absorbable for tissue engineering applications.

Keywords

biomaterialbiomedicalsintering
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1621: Symposium H/C/D/J – Advances in Structures, Properties and Applications of Biological and Bioinspired Materials , 2014 , pp. 93 - 99
Copyright
Copyright © Materials Research Society 2014 

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References

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