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New Nanocomposite Biomaterials Controlling Surface and Bulk Properties using Supercritical Carbon Dioxide

Published online by Cambridge University Press:  01 February 2011

Toru Hoshi ,
Takashi Sawagushi ,
Ryosuke Matsuno ,
Tomohiro Konno ,
Madoka Takai  and
Kazuhiko Ishihara
Toru Hoshi
Affiliation:
[email protected], The University of Tokyo, Department of Materials Engineering, School of Engineering, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan, +81-3-5841-7124, +81-3-5841-8647
Takashi Sawagushi
Affiliation:
[email protected], Nihon University, Department of Materials and Applied Chemistry, College of Science and Technology, 1-8-14, Kanda Surugadai, Chiyoda-ku,, Tokyo, 101-8308, Japan
Ryosuke Matsuno
Affiliation:
[email protected], The University of Tokyo, Department of Materials Engineering, School of Engineering,, 7-3-1, Hongo, Bunkyo-ku,, Tokyo, 113-8656, Japan
Tomohiro Konno
Affiliation:
[email protected], The University of Tokyo, Department of Materials Engineering, School of Engineering,, 7-3-1, Hongo, Bunkyo-ku,, Tokyo, 113-8656, Japan
Madoka Takai
Affiliation:
[email protected], The University of Tokyo, Department of Materials Engineering, School of Engineering,, 7-3-1, Hongo, Bunkyo-ku,, Tokyo, 113-8656, Japan
Kazuhiko Ishihara
Affiliation:
[email protected], The University of Tokyo, Department of Materials Engineering, School of Engineering,, 7-3-1, Hongo, Bunkyo-ku,, Tokyo, 113-8656, Japan
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Abstract

The molecular composite composed of polyethylene (PE) and poly(vinyl acetate) (PVAc) prepared using supercritical carbon dioxide (scCO2) and its surface modification for biocompatible surface demonstrated the creation of novel polymer biomaterials. In this study, this modification process was applied to the PE narrow tube (inside diameter: 300μm, outside diameter: 600μm, length: 5m). It was confirmed that PVAc was uniformly generated in PE tube by infrared imaging measurement of cross-section. After the acetyl group on the surface was hydrolyzed, phospholipid polymer was immobilized to the hydroxyl group on the surface of the tube. The phospholipid polymer immobilized surface showed a drastic reduction in protein adsorption. The surface of the minute and slender tube can be effectively modified using the feature of carbon dioxide whose surface tension is near zero. The modification technology by scCO2 is a promising for creation of variously-shaped new biomaterials.

Keywords

biomaterialpolymerinfrared (IR) spectroscopy
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1097: Symposium GG – Mechanical Behavior of Biological Materials and Biomaterials , 2008 , 1097-GG04-15
Copyright
Copyright © Materials Research Society 2008

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References

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