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Nanoscale heterostructures comprised of silicon nanowires and gold nanoparticles encapsulated in graphitic shells for DNA immobilization

Published online by Cambridge University Press:  24 July 2013

Yuan Li  and
Nitin Chopra
Yuan Li
Affiliation:
Metallurgical and Materials Engineering Department, Center for Materials for Information Technology (MINT), The University of Alabama, Tuscaloosa, AL 35487, U.S.A.
Nitin Chopra*
Affiliation:
Metallurgical and Materials Engineering Department, Center for Materials for Information Technology (MINT), The University of Alabama, Tuscaloosa, AL 35487, U.S.A. Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL 35487, U.S.A.
*
*Corresponding Author E mail: [email protected], Tel: 205-348-4153, Fax: 205-348-2164
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Abstract

Deoxyribonucleic acid (DNA) immobilization on nanoscale architectures is critical for developing bio-compatible devices and clinical diagnoses. In this study, silicon nanowires (SiNWs) were combined with gold nanoparticles encapsulated in graphitic shells (GNPs). The resulting SiNWs-GNPs heterostructures were plasma oxidized to create carboxylic (-COOH) functionality on the surface of the graphitic carbon shell. These heterostructures and their surface chemistries were studied using electron microscopy, Fourier transform infrared spectroscopy (FT-IR), and Raman spectroscopy. The –COOH terminated graphitic shells in heterostructures were covalently linked with DNA. The DNA molecules on these heterostructures were detected by linking with fluorescent streptavidin and observed under a fluorescence microscope. Such inorganic heterostructure-biomolecule assemblies can be very useful in the development of biomolecule analysis and detection devices.

Keywords

nanostructureRaman spectroscopybiomimetic (assembly)
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1572: Symposium SS – Bioelectronics—Materials, Interfaces and Applications , 2013 , mrss13-1572-ss06-08
Copyright
Copyright © Materials Research Society 2013 

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