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Nanoparticulate Hydroxyapatite Enhances the Bioactivity of a Resorbable Bone Graft

Published online by Cambridge University Press:  11 February 2011

Stephen A. Doherty ,
David D. Hile ,
Donald L. Wise ,
Jackie Y. Ying ,
Stephen T. Sonis  and
Debra J. Trantolo
Stephen A. Doherty
Affiliation:
Cambridge Scientific, Inc. 180 Fawcett Street, Cambridge, MA
David D. Hile
Affiliation:
Cambridge Scientific, Inc. 180 Fawcett Street, Cambridge, MA
Donald L. Wise
Affiliation:
Cambridge Scientific, Inc. 180 Fawcett Street, Cambridge, MA
Jackie Y. Ying
Affiliation:
Massachusetts Institute of Technology, Department of Chemical Engineering, Cambridge, MA
Stephen T. Sonis
Affiliation:
Harvard School of Dental Medicine, Dept. of Oral Medicine and Diagnostics Sciences, Boston, MA
Debra J. Trantolo
Affiliation:
Cambridge Scientific, Inc. 180 Fawcett Street, Cambridge, MA
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Abstract

A nanoparticulate-hydroxyapatite filler augmented osteointegration within a resorbable polymer based bone graft substitute designed for orthopaedic and periodontal applications. The unsaturated polyester poly(propylene glycol-co-fumaric acid) (PPF), was used to prepare the bone graft substitute. The nanoparticulate-hydroxyapatite filler was examined in terms of biocompatibility, bony ingrowth and mechanical stability in a rat calvarial defect model. The nano-hydroxyapatite fillerwas compared against a commercially available micrometer-sized hydroxyapatite(HA) filler. Histological analysis indicated that remodeling of the newly formed bone was more advanced in the defect filled with the nano-hydroxyapatite augmented PPF. Mechanical evaluation showed a more rapid increase in stiffness of the nano-hydroxyapatite PPF. Implants of the nano-HA augmented PPF showed more advanced bone formation and recovery of mechanical properties, suggesting an improved biological response to the nano-sized particles.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 735: Symposium C – Bioinspired Nanoscale Hybrid Systems , 2002 , C6.4
Copyright
Copyright © Materials Research Society 2003

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References

REFERENCES

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