Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-26T17:29:40.102Z Has data issue: false hasContentIssue false
  • English
  • Français

Nanobiohybrids: Bioinspired Sensors

Published online by Cambridge University Press:  01 February 2011

Nikolaos Chalkias  and
Emmanuel P. Giannelis
Nikolaos Chalkias
Affiliation:
Chemical and Biomolecular Engineering
Emmanuel P. Giannelis
Affiliation:
Materials Science and Engineering, Cornell University, Ithaca NY, Bard Hall 214, 14853
Get access

Abstract

Nanohybrid artificial membranes made by intercalation of amphiphilic molecules into the galleries of a layered host, exhibit characteristics similar to biological membranes and they can be used as sensors. Different responses have been observed even for molecules that have similar features for example, saccharin and its sodium salt suggesting that the nanohybrid might be useful in developing an electronic nose. The dynamic range of the saccharin sensor is 20 - 300μM. In this paper we present our results on sensor fabrication and testing and discuss possible sensing mechanisms. In addition, we describe our work on immobilizing in the nanohybrid membranes Glucose Oxidase, Horseradish Peroxidase and Gramicidin and evaluating their performance.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 873: Symposium K – Biological and Bio-Inspired Materials and Devices , 2005 , K9.5
Copyright
Copyright © Materials Research Society 2005

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

[1] Trojanowicz, M., “Miniaturized biochemical sensing devices based on planar bilayer lipid membranes,” Fresenius Journal of Analytical Chemistry, vol. 371, pp. 246–260, 2001.Google Scholar
[2] Worthington Biochemical Corporation., Worthington enzyme manual: enzymes, enzyme reagents, related biochemicals. Freehold, N.J.: Worthington Biochemical Corp., 1972.Google Scholar
[3] Bd, Ladbrook., Williams, R. M., and Chapman, D., “Studies on LecithinCholesterol-Water Interactions by Differential Scanning Calorimetry and X-Ray Diffraction,” Biochimica Et Biophysica Acta, vol. 150, pp. 333-&, 1968.Google Scholar
[4] Budavari, S., The Merck index: an encyclopedia of chemicals, drugs, and biologicals, 12th ed. Whitehouse Station, NJ: Merck, 1996.Google Scholar
[5] Housaindokht, M. R., Moosavimovahedi, A. A., Moghadasi, J., and Jones, M. N., “Interaction of Glucose-Oxidase with Ionic Surfactants - a Microcalorimetric Study,” International Journal of Biological Macromolecules, vol. 15, pp. 337–341, 1993.Google Scholar