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Multiscale Nanoporous Structures for Sensing and Diagnostics

Published online by Cambridge University Press:  31 January 2011

Shalini Prasad
Shalini Prasad*
Affiliation:
[email protected]
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Abstract

Current trends in sensing and diagnostics is towards developing hybrid devices that incorporate nanomaterial for enhancing device performance. These devices and systems have a broad impact ranging from personalized medicine in health care, environmental sensing and building multifunctional sensors for military applications. The overarching objective of the research work is to develop a new class of portable, bio-analytical tools with improved functionality and performance capabilities by utilizing the electrical effects on cellular and sub cellular species in micro and nanoscale domains.

There are two key ideas underlying this research work. The first is to design and manufacture structures comprising of nanoscale-confined spaces integrated on to multi-scale architecture platforms. This model architecture has been engineered to harness the principle of macromolecular crowding for biomolecule binding and detection by monitoring perturbations in the electrical bi-layer in tailored nanoscale confined spaces. Enhanced performance metrics in biomolecule detection have been demonstrated in developing electrical immunoassays. We have demonstrated picogram/ml sensitivity in detection of specific cardiovascular disease biomarkers, cancer biomarkers from human serum samples with a dynamic range of response varying from pg/ml to g/ml and response time within 120 seconds.

Keywords

sensornanostructuremicroelectronics
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1236: Symposium SS – Biosurfaces and Biointerfaces , 2009 , 1236-SS02-05
Copyright
Copyright © Materials Research Society 2010

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