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Monitoring the size and the stability of zinc oxide quantum dots in biological media: a soft ionization mass spectrometry technique (MALDI-TOF-MS)

Published online by Cambridge University Press:  17 June 2015

Jean-Jacques Gaumet ,
Gabriel Gaiffe ,
Clément Dezanet ,
Stéphane Dalmasso ,
Pierre Magri ,
Lavinia Balan  and
Raphaël Schneider
Jean-Jacques Gaumet
Affiliation:
Université de Lorraine, LCP-A2MC, Jean Barriol Institute, 1 bd Arago, 57078 Metz Cedex 03, France.
Gabriel Gaiffe
Affiliation:
Université de Lorraine, LCP-A2MC, Jean Barriol Institute, 1 bd Arago, 57078 Metz Cedex 03, France.
Clément Dezanet
Affiliation:
Université de Lorraine, LRGP, CNRS, UMR 7274, 1 rue Grandville, 54001 Nancy, France
Stéphane Dalmasso
Affiliation:
Université de Lorraine, LCP-A2MC, Jean Barriol Institute, 1 bd Arago, 57078 Metz Cedex 03, France.
Pierre Magri
Affiliation:
Université de Lorraine, LCP-A2MC, Jean Barriol Institute, 1 bd Arago, 57078 Metz Cedex 03, France.
Lavinia Balan
Affiliation:
IS2M, UHA, 15 rue Jean Starcky, BP 2488, 68057 Mulhouse Cedex, France
Raphaël Schneider
Affiliation:
Université de Lorraine, LRGP, CNRS, UMR 7274, 1 rue Grandville, 54001 Nancy, France
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Abstract

We present herein a joint physical/physico-chemical study and, more specifically, the first application of Matrix Assisted Laser Desorption Ionization coupled with Time of Flight Mass Spectrometry (MALDI-TOF-MS) to analyze small-sized ZnO quantum dots (QDs) (2.8-3.1 nm diameter range) synthesized by sol-gel chemistry and stabilized through an aminosilane coating. A careful investigation of the stability of ZnO QDs was initiated once these dots were dispersed in different media (water, biological buffer) for a period up to 3 weeks. Positive ion mode mass spectra MALDI-TOF-MS combined with optical spectrometry was used to monitor the stability of ZnO QDs when aging. Such a unique combination of MALDI-TOF-MS and physico-chemical techniques is likely to bring new insights into the structure analysis, the stability and consequently the potential toxicity of QDs.

Keywords

core/shellII-VImass spectroscopy
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1793: Symposium GG – Foundations of Bio/Nano Interfaces―Synthesis, Modeling, Design Principles and Applications , 2015 , pp. 7 - 12
Copyright
Copyright © Materials Research Society 2015 

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References

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