Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-25T15:43:19.008Z Has data issue: false hasContentIssue false
  • English
  • Français

Molecular Imprinted Hydrogels in Drug Delivery Applications

Published online by Cambridge University Press:  14 May 2015

Jeffrey S. Bates ,
Luke R. Whitson ,
Kelan M. Albertson ,
Nathan S. Hickerson ,
Patrick E. Nichols ,
Bethany E. Larson  and
Taylor D. Sparks
Jeffrey S. Bates
Affiliation:
Materials Science and Engineering, University of Utah, 122 S. Central Campus Drive, Room 304, Salt Lake City, UT 84112
Luke R. Whitson
Affiliation:
Materials Science and Engineering, University of Utah, 122 S. Central Campus Drive, Room 304, Salt Lake City, UT 84112
Kelan M. Albertson
Affiliation:
Materials Science and Engineering, University of Utah, 122 S. Central Campus Drive, Room 304, Salt Lake City, UT 84112
Nathan S. Hickerson
Affiliation:
Materials Science and Engineering, University of Utah, 122 S. Central Campus Drive, Room 304, Salt Lake City, UT 84112
Patrick E. Nichols
Affiliation:
Materials Science and Engineering, University of Utah, 122 S. Central Campus Drive, Room 304, Salt Lake City, UT 84112
Bethany E. Larson
Affiliation:
Materials Science and Engineering, University of Utah, 122 S. Central Campus Drive, Room 304, Salt Lake City, UT 84112
Taylor D. Sparks
Affiliation:
Materials Science and Engineering, University of Utah, 122 S. Central Campus Drive, Room 304, Salt Lake City, UT 84112
Get access

Abstract

Molecular imprinting is the process by which molecules are imprinted into the matrix of a material through non-covalent bonding, including hydrogen bonding and van der Waals interactions. In this study hydrogels were imprinted with glaucoma medication with the purpose of creating a reusable ocular drug delivery device with reversible binding sites. The material was synthesized and tested with UV-Vis spectroscopy to determine the concentration of the released drug after twelve hours in distilled water. Modifications were made to the polymer to explore methods required for the proper delivery of the drug over an adequate period of time.

Keywords

biomedicalpolymerpolymerization
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1797: Symposium KK – Nanomaterials in Translational Medicine , 2015 , mrss15-2132190
Copyright
Copyright © Materials Research Society 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Bates, J., Magda, J., pH-Responsive Hydrogels and their Applications in Chemomechanical Sensors, ScienceJet 4 (2014) 128.Google Scholar
West, J.L., Hubbell, J.A., Photopolymerized hydrogel materials for drug delivery applications, Reactive Polymers, 25 (1995) 139–147.CrossRefGoogle Scholar
Cunliffe, D., Kirby, A., Alexander, C., Molecularly imprinted drug delivery systems, Advanced Drug Delivery Reviews, 57 (2005) 1836–1853.Google ScholarPubMed
Herber, S., Bomer, J., Olthius, W., Bergveld, P., van den Berg, A., A miniaturized carbon dioxide gas sensor based on sensing of pH-sensitive hydrogel swelling with a pressure sensor, Biomedical Microdevices, 7 3 (2005) 197–204.CrossRefGoogle ScholarPubMed
Bates, J., Magda, J., Storage and Operational Stability of pH-Responsive Hydrogels, Global Journal of Science Frontier Research, 14 (2014) 6.Google Scholar
Bates, J., Magda, J., Chemomechanical pH Sensor Response Time and its Dependence on Hydrogel Thickness, Journal of Chemistry and Biochemistry (2015).Google Scholar
Bates, J., Tathireddy, P., Buetefisch, S., Magda, J., An Improved Design for Chemomechanical Sensors: The “Boss” Sensor, Chemosensors (2013).CrossRefGoogle Scholar
Ciolino, J.B., Hoare, T.R., Iwata, N.G., Behlau, I., Dohlman, C.H., Langer, R., Kohane, D. S. A drug-eluting contact lens, Investigative Ophthalmology and Visual Science, 50 7, (2009) 3346–3352.CrossRefGoogle ScholarPubMed
Gulsen, D., Chauhan, A., Ophthalmic drug delivery through contact lenses, Investigative Ophthalmology and Visual Science, 45 7 (2004) 2342–2347.CrossRefGoogle ScholarPubMed
Hu, X., Hao, L., Wang, H., Yang, H., Zhang, G., Wang, W., Zhang, X., Hydrogel contact lens for extended delivery of ophthalmic drugs, International Journal of Polymer Science, (2011) 1–9.CrossRefGoogle Scholar
Kearns, V.R., Williams, R.L., Drug delivery systems for the eye, Expert Review of Medical Devices, 6 3 (2009) 277–314.CrossRefGoogle ScholarPubMed
Lorenzo, C.A., Hiritani, H., Amoza, J.L.G., Pacheco, R.M., Souto, C., Concheiro, A., Soft contact lenses capable of sustained delivery of timolol, Journal of Pharmaceutical Sciences, 91 10 (2002) 2182–2192.CrossRefGoogle Scholar
Venkatesh, S., Saha, J., Pass, S., Byrne, M.E., Transport and structural analysis of molecular imprinted hydrogels for controlled drug delivery, European Journal of Pharmaceutics and Biopharmaceutics, 69 (2008) 852–860.CrossRefGoogle ScholarPubMed
Xinming, L., Yingde, C., Lloyd, A.W., Mikhalovsky, S.V., Sandeman, S.R., Howel, C.A., Liewen, L., Polymeric hydrogels for novel contact lens-based ophthalmic drug delivery systems: A review, Contact Lens and Anterior Eye, 31 (2008) 57–64.CrossRefGoogle ScholarPubMed
Alexander, C.L., Miller, S.J., Abel, S.R. Prostaglandin analog treatment of glaucoma and ocular hypertension, The Annals of Pharmacotherapy, 36 (2002) 504–511.CrossRefGoogle ScholarPubMed
Byrne, M.E., Park, K., Peppas, N.A., Molecular imprinting within hydrogels, Advanced Drug Delivery Reviews, 54 (2001) 149–161.CrossRefGoogle Scholar
Hillberg, A.L., Brain, K.R. Allender, C.J., Molecular imprinter polymer sensors: Implications for therapeutics, Advanced Drug Delivery Reviews, 57 (2005) 1875–1889.Google Scholar
Lorenzo, C.A., Concheiro, A., Molecularly imprinted polymers for drug delivery, Journal of Chromatography B, 801 (2004) 231–245.CrossRefGoogle Scholar
Stringer, R.C., Gangopadhyay, S., Grant, S.A., Comparison of molecular imprinted particles prepared using precipitation polymerization in water and chloroform for fluorescent detection of nitroaromatics, Analytical Chimica Acta, 703 (2011) 239–244.CrossRefGoogle ScholarPubMed
Vasapollo, G., Del Sol, R., Mergola, L., Lazzoi, M.R., Scardino, A., Scorrano, S., Mele, G., Molecularly imprinted polymers: present and future prospective, International Journal of Molecular Science, 12 (2011) 5908–5945.CrossRefGoogle ScholarPubMed
Hiratani, H., Lorenzo, C.A., The nature of backbone monomers determines the performance of imprinted soft contact lenses as timolol drug delivery systems, Biomaterials, 25 (2004) 1105–1113.CrossRefGoogle ScholarPubMed
Sato, S., Kitagawa, S., Nakajima, M., Shimada, K., Honda, A., Miyazaki, H., Assessment of tear concentrations on therapeutic drug monitoring, Pharmaceutical Research, 18 4 (2001) 500–509.CrossRefGoogle ScholarPubMed