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Modeling Receptor-Ligand Mediated Adhesion in Nanoindentation of Cells

Published online by Cambridge University Press:  26 February 2011

Zhang Chunyu  and
Zhang Yongwei
Zhang Chunyu
Affiliation:
[email protected], National University of Singapore, Materials Science and Engineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore, 119260, Singapore
Zhang Yongwei
Affiliation:
[email protected], National University of Singapore, Materials Science and Engineering, 10 Kent Ridge Crescent, 119260, Singapore
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Abstract

The specific adhesion mediated by receptor-ligand binding in the nanoindentation of cells was studied by using a continuum-kinetics approach. It was found that the adhesion force only causes a shift to the indentation loading curve whereas the unloading curve is tilted downward by the adhesion force, resulting in a hysteresis. Parametric studies were conducted to investigate how experimental conditions influence the adhesion force. It was found that the maximum adhesion force is sensitive to the geometry of the indenter but insensitive to the indentation depth and the mechanical properties of cells. It was also shown that the dependence of the adhesion force on the loading and unloading rates is controlled by the association rate of the receptor-ligand binding, leading to three well-defined regimes.

Keywords

adhesioncellular (material form)simulation
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 975: Symposium DD – Mechanics of Biological and Bio-Inspired Materials , 2006 , 0975-DD09-11
Copyright
Copyright © Materials Research Society 2007

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