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A Model for Oxygen Transport in Microencapsulated Islets

Published online by Cambridge University Press:  15 February 2011

H. Iwata ,
Y. G. Park  and
Y. Ikada
H. Iwata
Affiliation:
Research Center for Biomedical Engineering, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606, JAPAN
Y. G. Park
Affiliation:
Research Center for Biomedical Engineering, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606, JAPAN
Y. Ikada
Affiliation:
Research Center for Biomedical Engineering, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606, [email protected]
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Abstract

Oxygen supply is expected to be one of major limiting factors that determine survival of islets in microcapsules after transplantation. Fick's law is applied to derive equations describing the oxygen pressure (PO2) profiles. The PO2 profiles calculated demonstrate that the thickness of the microcapsule membrane does not significantly affect oxygen supply to the islet. On the other hand, it drastically decreases as the fibrous tissue surrounding the microcapsule becomes thicker. The islet will be destroyed non-immunologically by limiting oxygen supply, when the microencapsulated islets are surrounded by the thick fibrous tissue.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 530: Symposium CC – Biomaterials Regulating Cell Function & Tissue Development , 1998 , 19
Copyright
Copyright © Materials Research Society 1998

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References

1 Colton, C.K. and Avgoustiniatos, E. S., J. Biomech. Eng., 113, 152 (1991).Google Scholar
2 Lim, F., and Sun, A. M., Science, 210, 908 (1980).Google Scholar
3 Iwata, H., Takagi, T., Amemiya, H., Shimizu, H., Yamashita, K., Kobayashi, K., and Akutsu, T., J. Biomed. Mater. Res., 26, p.967 (1992).Google Scholar
4 Jansson, L. and Sandler, S., Diabetes., 38, 196(1989).Google Scholar
5 Groebe, K. and Mueller-Klieser, W., Eur. Biophys. J., 19, 169 (1991).Google Scholar
6 Muller-Klieser, W., Sutherland, R. M., Cancer Res., 42, 237 (1982).Google Scholar
7 Schrezenmeir, J., Kirchgessner, J., Gero, L., Kunz, L. A., Beyer, J. and Mueller-Klieser, W., Transplantation, 57, 1308 (1994).Google Scholar