Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-27T02:30:05.390Z Has data issue: false hasContentIssue false
  • English
  • Français

Microparticle filtration using carbon nanotubes and impedance characterisation for gold microelectrodes sensor system

Published online by Cambridge University Press:  31 January 2011

Ashish Mathur ,
Eyad M Hamad ,
Subhadeep Mukhopadhyay ,
Susanta Sinha Roy  and
Jim A McLaughlin
Ashish Mathur
Affiliation:
[email protected], University of Ulster, NIBEC, Belfast, Northern Ireland, United Kingdom
Eyad M Hamad
Affiliation:
[email protected], University of Ulster, NIBEC, Belfast, Northern Ireland, United Kingdom
Subhadeep Mukhopadhyay
Affiliation:
[email protected], University of Ulster, NIBEC, Belfast, Northern Ireland, United Kingdom
Susanta Sinha Roy
Affiliation:
[email protected]
Jim A McLaughlin
Affiliation:
[email protected], University of Ulster, NIBEC, Belfast, Northern Ireland, United Kingdom
Get access

Abstract

Blood-cell-free serum is required for most clinical chemistry tests. At present bend micro channel and polymeric pillars are used in polymer based microfluidic devices (such as PMMA) for the blood filtration. In this study, we have fabricated carbon nanotube (CNT) pillars on silicon from 20-50 μm in diameter with ˜10 μm spacing and integrate them inside the microfluidic channel with a view of using these for blood plasma filtration from whole blood, with passive capillary flow. Our main objective is to design a novel sensor, comprising CNT arrays, to filter/control whole blood flow, with an integrated micro patterned gold electrode which will be sealed by bonding into microfluidics structures. We have characterized the microfluidic channel by measuring the meniscus movement profiles. Also gold inter-digitated electrodes (IDEs) were fabricated on glass and immobilized with an antibody. These IDEs were used as an impedance-based biosensor using label-free antigen – antibody interaction. At a fixed frequency, the IDEs gave a linear response across the range of concentrations of secondary antibodies investigated (0 to 500 μg/mL).

Keywords

sensorchemical vapor deposition (CVD) (deposition)hot pressing
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1205: Symposium L – Large-Area Electronics from Carbon Nanotubes, Graphene, and Related Noncarbon Nanostructures , 2009 , 1205-L09-12
Copyright
Copyright © Materials Research Society 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

[1] Grant, S., Davis, F., Law, K. A., Barton, A. C., Collyer, S. D., Higson, S. P. J. and Gibson, T. D., Anal. Chim. Acta. 537, 163 (2005)Google Scholar
[2] Bakker, E. and Qin, Y., Anal. Chem. 78, 3965 (2006)Google Scholar
[3] Rahman, M. A., Shiddiky, M. J. A., Park, J. and Shim, Y., Biosens. Bioelectron. 22, 2464 (2007)Google Scholar
[4] Blanchet, G. and Rogers, J. J. Imaging Sci. Technol. 47, 296 (2003)Google Scholar
[5] Meitl, M. A., Yangxin, Z., Gaur, A., Seokwoo, J., Usrey, M. L., Strano, M. S. and Rogers, J. A. Nano Lett. 4, 1643 (2004)Google Scholar
[6] Barry, C. R., Lwin, N. Z., Zheng, W. and Jacobs, H. O. Appl. Phys. Lett. 83, 5527 (2003)Google Scholar
[7] Jacobs, H. O. and Whitesides, G. M. Science 291, 1763 (2001)Google Scholar
[8] Sun, Y. and Rogers, J. A. Nano Lett. 4, 1953 (2004)Google Scholar
[9] Allen, A. C., Sunden, E., Cannon, A., Graham, S. and King, W. Appl. Phys. Lett. 88, 083112 (2006)Google Scholar
[10] Sunden, E. O., Moon, J.K., Wong, C. P., King, W. P. and Graham, S. J. Vac. Sci. Technol. B 24, 1947 (2006)Google Scholar
[11] Mathur, A., Roy, S. S., Tweedie, M., Maguire, P. D., and McLaughlin, J. A. J. Nanosci.Nanotechnol. 9, 4392 (2009)Google Scholar
[12] Mathur, A., Roy, S. S., Tweedie, M., Mukhopadhyay, S., Mitra, S. K., and McLaughlin, J. A Curr. Appl. Phys. 9, 1199 (2009)Google Scholar
[13] Guan, J.G., Miao, Y. Q., & Zhang, Q. J, Biosci. Bioeng. 97, 219 (2004)Google Scholar
[14] Kim, K.S., Kyoung, Nam Lee and Roh, Y, Thin Solid Films. 516, 1489 (2008)Google Scholar
[15] Ko, S., Kim, B., Jo, S., Oh, S. Y. and Park, J., Biosens. Bioelectron. 23, 51 (2007)Google Scholar