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Macromolecular Nutriend Limitations of Encapsulated Cells

Published online by Cambridge University Press:  15 February 2011

Erik Einar Hancock  and
Linda Griffith Cima
Erik Einar Hancock
Affiliation:
Department of Chemical Engineering, Massachusetts Institute of Technology
Linda Griffith Cima
Affiliation:
Department of Chemical Engineering, Massachusetts Institute of Technology
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Abstract

Encapsulated cells are likely to encounter transport limitations of trace nutrients carried by macromolecules due to a high diffusion resistance in the encapsulating membrane. We modeled the transport of transferrin to encapsulated cells and found that the transport limitation of transferrin is potentially significant in comparison to oxygen, which is limiting in unencapsulated tissue. Since transferrin is the primary biological iron carrier, deprivation of transferrin to encapsulated cells may limit long term function and viability in vivo.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 331: Symposium T – Biomaterials for Drug and Cell Delivery , 1993 , 171
Copyright
Copyright © Materials Research Society 1994

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