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Investigation of Spreading and Traction of Human Osteosarcoma Cells on Microgrooved Polydimethylsilaxone Surfaces

Published online by Cambridge University Press:  01 February 2011

Yifang Cao ,
Jianbo Chen  and
Winston O. Soboyejo
Yifang Cao
Affiliation:
[email protected], Princeton University, Department of Mechanical and Aerospace Engineering, 1 Olden Street, Princeton, NJ, 08544, United States
Jianbo Chen
Affiliation:
[email protected], Princeton University, Dept of Mechanical and Aerospace Engineering and Princeton Institute for the Sci & Tech of Materials, Princeton, NJ, 08544, United States
Winston O. Soboyejo
Affiliation:
[email protected], Princeton University, Dept of Mechanical and Aerospace Engineering and Princeton Institute for the Sci & Tech of Materials, Princeton, NJ, 08544, United States
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Abstract

The paper presents the recent results of the spreading and traction of human osteosarcoma cells on soft polydimethylsiloxane (PDMS) microgrooved surfaces. The results show that the cell tractions resulted in significant deformation of the microgrooves. The tractions were calculated, and found to be in good agreement with the results from other studies. The results suggest that the cell spreading-induced soft substrate deformation needs to be considered in the design of implantable bioMEMS structures.

Keywords

cellular (material type)adhesionstress/strain relationship
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 950: Symposium D – Biosurfaces and Biointerfaces , 2006 , 0950-D03-07
Copyright
Copyright © Materials Research Society 2007

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