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Integrating Colloidal Quantum Dots with Porous Silicon for High Sensitivity Biosensing

Published online by Cambridge University Press:  21 March 2011

Girija Gaur ,
Dmitry Koktysh  and
Sharon M. Weiss
Girija Gaur
Affiliation:
Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN 37235, U.S.A.
Dmitry Koktysh
Affiliation:
Department of Chemistry, Vanderbilt Institute of Nanoscale Science and Engineering, Vanderbilt University, Nashville, TN 37235, USA
Sharon M. Weiss
Affiliation:
Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN 37235, U.S.A.
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Abstract

We aim to utilize the high surface area of a porous silicon (PSi) matrix coupled with semiconductor quantum dot (QD) amplifiers for ultrasensitive optical detection of small biomolecules using a dual-mode detection scheme. In our system, QDs attached to the target biomolecule serve as signal amplifiers by providing an additional refractive index increase beyond that of the smaller target molecules. The strong photoluminescence (PL) from the QDs serves as a secondary indication of target molecule attachment in the pores. A resulting increase in optical thickness of ∼190 nm and detection sensitivity of ∼700 nm/RIU have been demonstrated for attachment of glutathione capped CdTe QDs in the porous silicon matrix. Reflectance and PL measurements, combined with simulations, have been used to characterize the surface area coverage of the QDs within the porous framework, which is estimated at 10% for glutathione capped CdTe QDs.

Keywords

sensorluminescenceoptical
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1301: Symposium V/NN/OO/PP – Soft Matter, Biological Materials and Biomedical Materials—Synthesis, Characterization and Applications , 2011 , mrsf10-1301-pp06-03
Copyright
Copyright © Materials Research Society 2011

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References

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