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In vitro Apatite Deposition and Biodegradation of Porous Gelatin-Silicate Hybrids Derived from Sol-Gel Process

Published online by Cambridge University Press:  01 February 2011

Lei Ren ,
Kanji Tsuru ,
Satoshi Hayakawa  and
Akiyoshi Osaka
Lei Ren
Affiliation:
Biomaterial Laboratory, Faculty of Engineering, Okayama University, Tsushima, Okayama-shi, 700–8530, Japan
Kanji Tsuru
Affiliation:
Biomaterial Laboratory, Faculty of Engineering, Okayama University, Tsushima, Okayama-shi, 700–8530, Japan
Satoshi Hayakawa
Affiliation:
Biomaterial Laboratory, Faculty of Engineering, Okayama University, Tsushima, Okayama-shi, 700–8530, Japan
Akiyoshi Osaka
Affiliation:
Biomaterial Laboratory, Faculty of Engineering, Okayama University, Tsushima, Okayama-shi, 700–8530, Japan
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Abstract

Ca (II) containing porous hybrids of gelatin and 3-(glycidoxypropyl) trimethoxysilane (GPSM) were prepared with sol-gel processing and freeze-drying techniques. The freezing temperature could control porosity and pore size of the hybrids. The biodegradation rate of the hybrids in a Tris buffer solution decreased with an increase in GPSM content. The bone-like apatite layer could form on the Ca (II) containing porous gelatin-silicate hybrids when they were soaked in a stimulated body fluid (SBF), hence they were applicable to be the bioactive scaffolds for bone tissue engineering.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 628: Symposium CC – Hybrid Organic/Inorganic Materials , 2000 , CC10.6
Copyright
Copyright © Materials Research Society 2000

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References

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