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Improvement of solubility and biocompatibility of MnO based nanoparticles in aqueous solutions

Published online by Cambridge University Press:  28 June 2011

Kerstin Koll ,
Thomas D. Schladt ,
Stefan Weber ,
Florian D. Jochum ,
Patrick Theato ,
Laura M. Schreiber  and
Wolfgang Tremel
Kerstin Koll
Affiliation:
Institut für anorganische und analytische Chemie, Johannes-Gutenberg Universität, Duesbergweg 10-14, 55099 Mainz, Germany
Thomas D. Schladt
Affiliation:
IBM Almaden Research Center, San Jose, CA 95120-6099 TN 37831-6376, U.S.A.
Stefan Weber
Affiliation:
Institut für medizinische Physik, Klinik und Polyklinik für diagnostische und interventionelle Radiologie, Universitätsklinikum Mainz (Germany)
Florian D. Jochum
Affiliation:
Institut für organische Chemie, Johannes Gutenberg-Universität Mainz (Germany)
Patrick Theato
Affiliation:
Institut für organische Chemie, Johannes Gutenberg-Universität Mainz (Germany)
Laura M. Schreiber
Affiliation:
Institut für medizinische Physik, Klinik und Polyklinik für diagnostische und interventionelle Radiologie, Universitätsklinikum Mainz (Germany)
Wolfgang Tremel
Affiliation:
Institut für anorganische und analytische Chemie, Johannes-Gutenberg Universität, Duesbergweg 10-14, 55099 Mainz, Germany
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Abstract

MnO nanoparticles were surface modified using two different multifunctional polymers. By introducing a PEG group, the long term stability, MRI applicability and sterile filtration could be greatly improved. Furthermore, PEGylated MnO NPs were less toxic compared to non-PEGylated NPs. The results suggest that these nanoparticles are suitable for in vivo applications.

Keywords

nanostructureMnbiomedical
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1346: Symposium AA – Micro- and Nanofluidic Systems for Materials Synthesis, Device Assembly and Bioanalysis , 2011 , mrss11-1346-aa10-01
Copyright
Copyright © Materials Research Society 2011

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References

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