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α-Helical Polypeptide Materials

Published online by Cambridge University Press:  15 February 2011

E. P. Enriquez ,
M. Y. Jin ,
R. C. Jarnagin  and
E. T. Samulski
E. P. Enriquez
Affiliation:
Dept. of Chemistry, University of North Carolina, Chapel Hill, NC 27599–3290
M. Y. Jin
Affiliation:
Dept. of Chemistry, University of North Carolina, Chapel Hill, NC 27599–3290
R. C. Jarnagin
Affiliation:
Dept. of Chemistry, University of North Carolina, Chapel Hill, NC 27599–3290
E. T. Samulski
Affiliation:
Dept. of Chemistry, University of North Carolina, Chapel Hill, NC 27599–3290
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Abstract

Poly(γ-benzyl-L-glutamate) (PBLG) may be derivatized on its periphery by covalently attaching χ-active NLO chromophores at the termini of its sidechains and thereby give a new class of SHG materials. The inherent liquid crystalline properties of concentrated solutions of α-helical PBLG may be exploited to establish unique supramolecular structures prior to E-field poling. When PBLG is derivatized at its N-terminus with lipoic acid, it will self-assemble on gold to give a thin film. Angle-dependent XPS, ellipsometry, contact angle measurements, and grazing angle IR reflection-absorption spectroscopy give quantitative information about the orientation of the polypeptide α-helices relative to the substrate surface. Consequently, polypeptides, in particular, Merrifield-synthesized or recombinant DNA-expressed synthetic polypeptides, present a novel fabrication route to thin films wherein molecular-engineered functionalities (chemical, electrical, or optically active species) may be encoded into the macromolecule's primary structure and subsequently expressed spatially via the spontaneous self-organization of these rod-like polymers.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 292: Symposium S – Biomolecular Materials , 1992 , 163
Copyright
Copyright © Materials Research Society 1993

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