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Functionalized Regioregular Polyalkylthiophenes for Biosensing Applications

Published online by Cambridge University Press:  01 February 2011

Simon J. Higgins ,
Fouzi Mouffouk ,
Stewart J. Brown ,
Naser Sedghi ,
Bill Eccleston  and
Stuart Reeman
Simon J. Higgins
Affiliation:
Department of Chemistry, University of Liverpool, Crown Street, LIVERPOOL L69 7ZD, U.K.
Fouzi Mouffouk
Affiliation:
Department of Chemistry, University of Liverpool, Crown Street, LIVERPOOL L69 7ZD, U.K.
Stewart J. Brown
Affiliation:
Department of Chemistry, University of Liverpool, Crown Street, LIVERPOOL L69 7ZD, U.K.
Naser Sedghi
Affiliation:
Department of Electrical and Electronic Engineering, University of Liverpool, Brownlow Hill, LIVERPOOL L69 3GJ, U.K.
Bill Eccleston
Affiliation:
Department of Electrical and Electronic Engineering, University of Liverpool, Brownlow Hill, LIVERPOOL L69 3GJ, U.K.
Stuart Reeman
Affiliation:
Dstl Chemical and Biological Sciences, SALISBURY, SP4 0JQ, U.K.
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Abstract

A regioregular copolymer of 3–hexylthiophene and 3–(6–hydroxyhexan–1yl)thiophene has been functionalised with biotin hydrazide; binding of avidin to the biotin moieties causes drastic changes to the absorption spectrum of the polymer in solution, and to the electrochemistry and conductivity of the polymer in thin films.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 871: Symposium I – Organic Thin-Film Electronics , 2005 , I1.3
Copyright
Copyright © Materials Research Society 2005

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References

1 Roncali, J., Chem. Revs. 92, 711 (1992); J. Mater. Chem. 9, 1875 (1999).Google Scholar
2 Loewe, R. S., Khersonsky, S. M., and McCullough, R. D., Adv. Mater. 11, 250 (1999); R. S. Loewe, P. C. Ewbank, J. S. Liu, L. Zhai, and R. D. McCullough, Macromolecules 34, 4324 (2001)Google Scholar
3 McCullough, R. D., Adv. Mater. 10, 93 (1998); T. Yamamoto, D. Komarudin, M. Arai, B. L. Lee, H. Suganuma, N. Asakawa, Y. Inoue, K. Kubota, S. Sasaki, T. Fukuda, and H. Matsuda, J. Am. Chem. Soc. 120, 2047 (1998).Google Scholar
4 Sirringhaus, H., Brown, P. J., Friend, R. H., Nielsen, M. M., Bechgaard, K., LangeveldVoss, B. M. W., Spiering, A. J. H., Janssen, R. A. J., Meijer, E. W., Herwig, P., and deLeeuw, D. M., Nature 401, 685 (1999); N. M. Sedghi, G. R. Lloyd, M. Raja, W. Eccleston, R. D. Lucrezia, and S. J. Higgins, J. Appl. Phys. 92, 1441 (2002).Google Scholar
5 Zhai, L., Pilston, R. L., Zaiger, K. L., Stokes, K. K., and McCullough, R. D., Macromolecules 36, 61 (2003).Google Scholar
6 Reitzel, N., Greve, D. R., Kjaer, K., Hows, P. B., Jayaraman, M., Savoy, S., McCullough, R. D., McDevitt, J. T., and Bjornholm, T., J. Am. Chem. Soc. 122, 5788 (2000).Google Scholar
7 Wilchek, M. and Bayer, E. A., Anal. Biochem. 171, 1 (1988); M. Wilchek and E. A. Bayer (editors), Methods in Enzymology 184, Avidin-Biotin Technology (Academic Press, San Diego, USA, 1990); M. D. Savage, G. Mattson, S. Desai, G. W. Nielander, S. Morgensen, and E. J. Conklin, Avidin-Biotin Chemistry: A Handbook (Pierce Chemical Co., Rockford, Ill., USA, 1992).Google Scholar
8 Bernier, S., Garreau, S., Béra-Abérem, M., Gravel, C., and Leclerc, M., J. Am. Chem. Soc. 124, 12463 (2002).Google Scholar
9 Wilson, J.N., Wang, Y., Lavigne, J.J. and Bunz, U.H.F., Chem. Commun. 2003, 1626.Google Scholar
10 Higgins, S.J., Mouffouk, F., Brown, S.J., Sedghi, N., Eccleston, B. and Reeman, S., Chem. Commun. 2004, 2314.Google Scholar