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Functionalized Magnetic Nanoparticles for Selective Targeting of Cells

Published online by Cambridge University Press:  01 February 2011

Wolfgang Tremel ,
Mohammed Ibrahim Shukoor ,
Filipe Natalio ,
Muhammad Nawaz Tahir ,
Matthias Wiens ,
Thomas Schladt ,
Matthias Barz ,
Patrick Theato ,
Heinz Christoph Schröder  and
Werner Müller
Wolfgang Tremel
Affiliation:
[email protected], United States
Mohammed Ibrahim Shukoor
Affiliation:
[email protected], Universität Mainz, Institut für Anorganische Chemie und Analytische Chemie, Mainz, Germany
Filipe Natalio
Affiliation:
[email protected], Universität Mainz, Institut für Physiologische Chemie, Mainz, Germany
Muhammad Nawaz Tahir
Affiliation:
[email protected], Universität Mainz, Institut für Anorganische Chemie und Analytische Chemie, Mainz, Germany
Matthias Wiens
Affiliation:
[email protected], Universität Mainz, Institut für Physiologische Chemie, Mainz, Germany
Thomas Schladt
Affiliation:
[email protected], Universität Mainz, Institut für Anorganische Chemie und Analytische Chemie, Mainz, Germany
Matthias Barz
Affiliation:
[email protected], Universität Mainz, Institut für Organische Chemie, Mainz, Germany
Patrick Theato
Affiliation:
[email protected], Universität Mainz, Institut für Organische Chemie, Mainz, Germany
Heinz Christoph Schröder
Affiliation:
[email protected], Universität Mainz, Institut für Physiologische Chemie, Mainz, Germany
Werner Müller
Affiliation:
[email protected], Universität Mainz, Institut für Physiologische Chemie, Mainz, Germany
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Abstract

MnO nanoparticles were conjugated to single stranded DNA (ssDNA), Cytosin-phosphatidyl-Guanosin oligonucleotide (CpG ODN) to detect and activate Toll-like (TLR9) receptors in cells and to follow nanoparticle cellular trafficking by different means of imaging while at the same time serving as a drug carrier system. By virtue of their magnetic properties these nanoparticles may serve as vehicles for the transport of target molecules into cells, while the fluorescent target ligand allows optical detection simultaneously.x

Keywords

nanostructuresurface chemistrymagnetic
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1140: Symposium HH – Advances in Material Design for Regenerative Medicine, Drug Delivery and Targeting/Imaging , 2008 , 1140-HH12-01
Copyright
Copyright © Materials Research Society 2009

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References

REFERENCES

1. Pamer, E. G., Nat. Immunol. 8, 1173 (2007).Google Scholar
2. Takeda, K., Kaisho, T., Akira, S., Annu. Rev. Immunol. 21, 335 (2003).Google Scholar
3. Re, F., Strominger, J. L., Immunobiology 209, 191 (2004).Google Scholar
4. (a) Lee, G. H., Huh, S. H., Jeong, J.W., Choi, B. J., Kim, S. H., Ri, H.-C., J. Am. Chem. Soc. 124, 12094 (2004).10.1021/ja027558mGoogle Scholar
(b) Yin, M., O'Brien, S., J. Am. Chem. Soc. 125, 10180 (2003).Google Scholar
(c) Seo, W. S., Jo, H. H., Lee, K., Kim, B., Oh, S. J., Park, J. T., Angew. Chem. Int. Ed. 43, 1115 (2004).Google Scholar
5. Tahir, M. N., Eberhardt, M., Theato, P., Faiβ, S., Janshoff, A., Gorelik, T., Kolb, U., Tremel, W., Angew. Chem. Int. Ed. 45, 908 (2006).Google Scholar
6. Chu, B. C. F., Wahl, G. M., Orgel, L. E., Nucl. Acids Res. 11, 6513 (1983).Google Scholar
7. Tahir, M. N., Eberhardt, M., Theato, P., Faiss, S., Janshoff, A., Gorelik, T., Kolb, U., Tremel, W., Angew. Chem. Int. Ed. 45, 908 (2006).Google Scholar
8. Leifer, C. A., Kennedy, M. N., Mazzoni, A., Lee, C. W., Kruhlak, M. J., Segal, D. M., J. Immun. 173, 1179 (2004).Google Scholar
9. Barton, G. M., Kagan, J. C., Medzhitov, R., Nat. Immun. 7, 49 (2006).Google Scholar
10. (a) Ahmad-Nejad, P., Häcker, H., Rutz, M., Bauer, S., Vabulas, R. M., Wagner, H., Eur. J. Immunol. 32, 1958 (2002).Google Scholar
11. Leifer, C.A., Brooks, J. C., Hoelzer, K., Lopez, J., Kennedy, M. N., Mazzoni, A., Segal, D. M., J. Biol. Chem. 281, 35585 (2006).Google Scholar