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Fabrication of Ring-shaped Bioactuator Powered by Cardiomyocytes

Published online by Cambridge University Press:  01 February 2011

Hiroshi Horiguchi ,
Yoshitake Akiyama  and
Keisuke Morishima
Hiroshi Horiguchi
Affiliation:
[email protected], Tokyo University of Agriculture and Technology, Department of Mechanical Systems Engineering, 2-24-16 Nakachou, Koganei, Tokyo, N/A, Japan
Yoshitake Akiyama
Affiliation:
[email protected], Tokyo University of Agriculture and Technology, Department of Mechanical Systems Engineering, 2-24-16 Nakachou, Koganei, Tokyo, 184-8588, Japan
Keisuke Morishima
Affiliation:
[email protected], Tokyo University of Agriculture and Technology, Department of Mechanical Systems Engineering, 2-24-16 Nakachou, Koganei, Tokyo, 184-8588, Japan
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Abstract

We have proposed a novel use of pulsating living cells as a driving source for a micro bio-actuator. Cardiyomyocytes contract autonomously using chemical energy. But, contractile force of a single cardiomyocyte is not enough to actuate a micro robot or a mechanical system. So it is necessary to reconstruct cardiomyocytes to increase the ability to contract. We focused on the reconstruction of cardiomyocytes using a basement membrane protein mixture. In this paper, we fabricated a prototype cardiomyocyte gel structure. We confirmed that the ring-shaped cardiomyocyte gel structure condensed around the central cylinder within the PDMS mold and contracted synchronously and autonomously.

Keywords

microelectro-mechanical (MEMS)biomaterialmicrostructure
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1096: Symposium FF – Molecular Motors, Nanomachines and Active Nanostructures , 2008 , 1096-FF03-26
Copyright
Copyright © Materials Research Society 2008

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