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Fabrication and Characterization of Calcium Phosphate / Porous Silicon / Silicon Structures Doped with Platinum Antitumor Compounds

Published online by Cambridge University Press:  10 February 2011

Jeffery L. Coffer ,
Xin Li ,
John St. John ,
Russell F. Pinizzotto ,
Yandong Chen ,
Jon Newey  and
Leigh T. Canham
Jeffery L. Coffer
Affiliation:
Texas Christian University, Fort Worth, TX 76129
Xin Li
Affiliation:
Texas Christian University, Fort Worth, TX 76129
John St. John
Affiliation:
Texas Christian University, Fort Worth, TX 76129
Russell F. Pinizzotto
Affiliation:
University of North Texas, Denton, TX 76203
Yandong Chen
Affiliation:
University of North Texas, Denton, TX 76203
Jon Newey
Affiliation:
DERA, Malvern Worcestershire, WR143PS UK
Leigh T. Canham
Affiliation:
DERA, Malvern Worcestershire, WR143PS UK
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Abstract

A process has been developed which permits the encapsulation of an established class of platinum anticancer drugs such as cis-Platin (cis-diammine-dichloroplatinum (II)) within synthetic biocompatible calcium phosphate films that are electrochemically-grown on porous Si/Si substrates. These platinum complex-doped hydroxyapatite / porous Si / Si materials have been characterized by scanning electron microscopy (SEM), energy dispersive x-ray spectroscopy (XEDS), and secondary ion mass spectrometry (SIMS). Upon immersion of these structures into aqueous media, the desired platinum species can be released into the surrounding environment. This study also focuses on the influence of initial platinum concentration for a given complex in the deposition process on the rate and resultant amount of platinum complex that can be delivered to the surroundings in vitro. Both inductively-coupled plasma (ICP) spectroscopy and uv-visible absorption spectrometry have been employed to monitor the release of the encapsulated drug from the calcium phosphate layers.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 599: Symposium DD – Mineralization in Natural & Synthetic Biomaterials , 1999 , 61
Copyright
Copyright © Materials Research Society 2000

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