Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-20T00:26:47.723Z Has data issue: false hasContentIssue false
  • English
  • Français

Enhanced Osteoblast Functions on Nanophase Titania in Poly-lactic-co-glycolic Acid (PLGA) Composites

Published online by Cambridge University Press:  01 February 2011

Huinan Liu ,
Elliott B. Slamovich  and
Thomas J. Webster
Huinan Liu
Affiliation:
School of Materials Engineering, 501 Northwestern Avenue
Elliott B. Slamovich
Affiliation:
School of Materials Engineering, 501 Northwestern Avenue
Thomas J. Webster
Affiliation:
School of Materials Engineering, 501 Northwestern Avenue Weldon School of Biomedical Engineering, 500 Central Drive Purdue University, West Lafayette, IN 47907, U.S.A.
Get access

Abstract

Much work is needed in the design of more effective bone tissue engineering materials to induce the growth of normal bone tissue. Nanotechnology offers exciting alternatives to traditional bone implants since bone itself is a nanostructured material composed of nanofibered hydroxyapatite well-dispersed in a mostly collagen matrix. For this purpose, poly-lactic-co-glycolic acid (PLGA) was dissolved in chloroform and nanometer grain size titania was dispersed by various sonication powers from 0 W to 166 W. Previous results demonstrated that the dispersion of titania in PLGA was enhanced by increasing the intensity of sonication and that greater osteoblast (bone-forming cells) adhesion correlated with improved nanophase titania dispersion in PLGA. However, adhesion of osteoblasts to material surfaces, alone, is not adequate to determine long-term functions of implant materials. For this reason, and as a next step to determine the efficacy of nanocomposites in bone applications, subsequent functions of osteoblasts on nanophase titania/PLGA composites were investigated in vitro in this study. For the first time, results correlated better osteoblast long-term functions, specifically the deposition of calcium-containing mineral, with improved nanophase titania dispersions in PLGA.In this manner, the present study demonstrated that PLGA composites with well-dispersed nanophase titania can improve osteoblast functions necessary for the further investigation of these materials in orthopedic applications.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 845: Symposium AA – Nanoscale Materials Science in Biology and Medicine , 2004 , AA5.33
Copyright
Copyright © Materials Research Society 2005

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Boccaccini, A. R. and Maquet, V., Composite Science and Technology, 63, 2417–2429 (2003).Google Scholar
2. Hutmacher, D. W., Biomaterials, 21, 2529–2543 (2000).Google Scholar
3. Thomson, R.C., Yaszemski, M.J., Powers, J.M., and Mikos, A.G., Biomaterials, 19, 1935–1943 (1998).Google Scholar
4. Landers, R., Huebner, U., Schmelzeisen, R., and Muelhaupt, R., Biomaterials, 23, 4437–4447 (2002).Google Scholar
5. Weng, J. and Wang, M., Journal of Materials Science Letters, 20, 1401–1403 (2001).Google Scholar
6. Zhang, Y. and Zhang, M., Journal of Biomedical Materials Research, 55, 304–312 (2001).Google Scholar
7. Slivka, M.A., Leatherbury, N.C., Kieswetter, K., and Niederauer, G., Tissue Engineering, 7(6), 767–780 (2001).Google Scholar
8. Vance, R.J., Miller, D.C., Thapa, A., Haberstroh, K.M. and Webster, T.J., Biomaterials, 25, 2095–2103 (2004).Google Scholar
9. Kim, H., Kim, H.W., and Suh, H., Biomaterials, 24, 4671–4679 (2003).Google Scholar
10. Maquet, V., Boccaccini, A.R., Pravata, L., Notingher, I. and Jerome, R., Biomaterials, 25, 4185–4194 (2004).Google Scholar
11. Lu, W.W., Zhao, F., Luk, K.D.K., and Yin, Y.J., et al., Journal of Materials Science: Materials in Medicine, 14, 1039–1046 (2003).Google Scholar
12. Ma, P.X., Zhang, R., Xiao, G. and Franceschi, R., Journal of Biomedical Materials Research, 54(2), 284–293 (2001).Google Scholar
13. Petite, H., Viateau, V., Bensaid, W., and Meunier, A., et al., Natural Biotechnology, 18(9), 959–963 (2000)Google Scholar
14. Stamboulis, A.G., Hench, L.L., and Boccaccini, A.R., Journal of Materials Science: Materials in Medicine, 13(9), 843–848 (2002).Google Scholar
15. Blaker, J. J., Gough, J. E., Maquet, V., Notingher, I., and Boccaccini, A. R., Journal of Biomedical Materials Research - Part A, 67(4), 1401–1411 (2003).Google Scholar
16. Marra, K.G., Szem, J.W., Kumta, P.N., DiMilla, P.A., and Weiss, L.E., Journal of Biomedical Materials Research, 47(3), 324–335 (1999).Google Scholar
17. Kalita, S.J., Bose, S., Hosick, H.L., and Bandyopadhyay, A., Materials Science and Engineering C, 23(5), 611–620 (2003).Google Scholar
18. Boccaccini, A.R., Roether, J.A., Hench, L.L., Maquet, V., and Jerome, R., Ceramic Engineering and Science Proceedings, 23(4), 805–816 (2002).Google Scholar
19. Dulgar, A.J., Bizios, R., and Siegel, R.W., Materials Research Society Symposium Proceedings, 740, 161–166 (2003).Google Scholar
20. Kalita, S., Finley, J., Bose, S., Hosick, H. and Bandyopadhyay, A., Materials Research Society Symposium Proceedings, 726, 91–96 (2002).Google Scholar
21. Webster, T.J., Siegel, R.W., and Bizios, R., Biomaterials, 20, 1221–1277 (1999).Google Scholar
22. Webster, T.J., Ergun, C., Doremus, R.H., and Siegel, R.W., Biomaterials, 21, 1803–1810 (2000).Google Scholar
23. Webster, T.J., Siegel, R.W., and Bizios, R., Nanostructured Materials, 12(5), 983–986 (1999).Google Scholar
24. Webster, T.J. and Smith, T.A., Journal of Biomedical Materials Research, (2004) (in press).Google Scholar
25. Liu, H., Slamovich, E.B. and Webster, T.J., American Ceramic Society Annual Meeting Proceedings, (2004) (in press).Google Scholar