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Enhanced Biocompatibility of GPC by MeV Ion Bombardment

Published online by Cambridge University Press:  01 February 2011

R. Zimmerman ,
I. Gurhan ,
S. Sarkisov ,
C. Muntele ,
D. Ila  and
M. Rodrigues
R. Zimmerman
Affiliation:
Center for Irradiation of Materials, Alabama A&M University, Normal, AL
I. Gurhan
Affiliation:
Ege University Faculty of Engineering, Izmir, Turkey
S. Sarkisov
Affiliation:
Center for Irradiation of Materials, Alabama A&M University, Normal, AL
C. Muntele
Affiliation:
Center for Irradiation of Materials, Alabama A&M University, Normal, AL
D. Ila
Affiliation:
Center for Irradiation of Materials, Alabama A&M University, Normal, AL
M. Rodrigues
Affiliation:
University of Sao Paulo, Ribeirao Preto SP Brazil
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Abstract

Glassy Polymeric Carbon (GPC) is completely biocompatible and is widely used as a material for artificial heart valves and in other biomedical applications. Although it is ideally suited for fluid flow in the blood stream, collagenous tissue that normally forms around the moving parts of a GPC heart valve sometimes loses adhesion and creates embolisms downstream. We have shown that moderate fluence of MeV ions, especially oxygen ions, increases the surface roughness of GPC on a scale appropriate for enhancing tissue adhesion. Silver ion implantation is shown to inhibit cell growth on GPC. Ion bombardment also increases the surface hardness of GPC, already an extremely hard material. In vitro biocompatibility tests have been carried out with model cell lines to demonstrate that MeV ion bombardment can favorably influence the surface of GPC for biomedical applications.

Keywords

Carbon biomaterialsCarbonTissue adhesion
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 873: Symposium K – Biological and Bio-Inspired Materials and Devices , 2005 , K3.10
Copyright
Copyright © Materials Research Society 2005

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